Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway

被引：11
|
作者：
Yang, Jen-Tsung [1 ,2 ]
Lee, I-Neng [3 ]
Lu, Fung-Jou [4 ]
Chung, Chiu-Yen [1 ]
Lee, Ming-Hsueh [1 ]
Cheng, Yu-Ching [1 ]
Chen, Kuo-Tai [1 ]
Chen, Ching-Hsein [5 ]
机构：
[1] Chang Gung Mem Hosp, Dept Neurosurg, Chiayi 61363, Taiwan
[2] Chang Gung Univ, Coll Med, Tao Yuan 33302, Taiwan
[3] Chang Gung Mem Hosp, Dept Med Res, Chiayi 61363, Taiwan
[4] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[5] Natl Chiayi Univ, Coll Life Sci, Dept Microbiol Immunol & Biopharmaceut, Chiayi 60004, Taiwan
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2017年 / 2017卷
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED APOPTOSIS; CANCER CELLS; GLIOBLASTOMA; MIGRATION; INVASION; ENHANCEMENT; ACTIVATION; EXPRESSION; ACID;
D O I：
10.1155/2017/9489383
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZtreated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-.B pathway and possibly provide a novel prospective strategy for treating malignant glioma.
引用
收藏
页数：12
相关论文
共 50 条
  • [41] CCN1 Promotes Mesenchymal Phenotype Transition Through Activating NF-κB Signaling Pathway Regulated by S100A8 in Glioma Stem Cells
    Guo, Xing
    Guo, Shuhua
    Tian, Feng
    Gao, Zijie
    Fan, Yang
    Wang, Chuanxin
    Xu, Shuo
    CNS NEUROSCIENCE & THERAPEUTICS, 2024, 30 (12)
  • [42] Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/IκB/NF-κB Pathway on Human Umbilical Vein Endothelial Cells
    Zhang, Shaoyang
    Cheng, Meili
    Wang, Zhen
    Liu, Yuzhi
    Ren, Yuhua
    Rong, Shikuo
    Wang, Xue
    MEDIATORS OF INFLAMMATION, 2020, 2020
  • [43] SENP2 exerts an anti-tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF-B signaling pathways
    Chen, Xiu-Li
    Wang, Shi-Fen
    Liang, Xue-Ting
    Liang, Hui-Xin
    Wang, Ting-Ting
    Wu, Shun-Quan
    Qiu, Zong-Jian
    Zhan, Rong
    Xu, Zhen-Shu
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2019, 54 (02) : 455 - 466
  • [44] Prunetin Triggers ROS-mediated Apoptosis through the Suppression of MAPKs/STAT-3/NF-κB-p65 Signaling Pathway in Human Osteosarcoma Cells
    Gao, Meng
    Wang, Ya
    Liu, Weibo
    Song, Zelong
    Wang, Xiangyu
    Zhang, Xuesong
    PHARMACOGNOSY MAGAZINE, 2024, 20 (01) : 336 - 346
  • [45] BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-κB/MGMT signaling pathway
    Li, Mao
    Liang, Ruo Fei
    Wang, Xiang
    Mao, Qing
    Liu, Yan Hui
    ONCOLOGY LETTERS, 2017, 14 (06) : 6597 - 6603
  • [46] OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells
    Perez, Lorena
    Vallejos, Alejandro
    Echeverria, Cesar
    Varela, Diego
    Cabello-Verrugio, Claudio
    Simon, Felipe
    LABORATORY INVESTIGATION, 2019, 99 (03) : 421 - 437
  • [47] CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway df
    Long, T. Y.
    Jing, R.
    Kuang, F.
    Huang, L.
    Qian, Z. X.
    Yang, T. L.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2017, 50 (04)
  • [48] 17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/ NF-κB Pathway
    Li, Pei
    Gan, Yibo
    Xu, Yuan
    Wang, Liyuan
    Ouyang, Bin
    Zhang, Chengmin
    Luo, Lei
    Zhao, Chen
    Zhou, Qiang
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 13 (02): : 145 - 156
  • [49] Diallyl Disulfide Suppresses the Inflammation and Apoptosis Resistance Induced by DCA Through ROS and the NF-κB Signaling Pathway in Human Barrett's Epithelial Cells
    Feng, Cheng
    Luo, Yumei
    Nian, Yuanyuan
    Liu, Dong
    Yin, Xiaoran
    Wu, Jing
    Di, Jia
    Zhang, Rong
    Zhang, Jun
    INFLAMMATION, 2017, 40 (03) : 818 - 831
  • [50] TREM-1 promoted apoptosis and inhibited autophagy in LPS-treated HK-2 cells through the NF-κB pathway
    Pan, Pan
    Liu, Xudong
    Wu, LingLing
    Li, Xiaogang
    Wang, Kaifei
    Wang, Xiaoting
    Zhou, Xiang
    Long, Yun
    Liu, Dawei
    Xie, Lixin
    Su, Longxiang
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2021, 18 (01): : 8 - 17
12345