Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway

被引：11
|
作者：
Yang, Jen-Tsung [1 ,2 ]
Lee, I-Neng [3 ]
Lu, Fung-Jou [4 ]
Chung, Chiu-Yen [1 ]
Lee, Ming-Hsueh [1 ]
Cheng, Yu-Ching [1 ]
Chen, Kuo-Tai [1 ]
Chen, Ching-Hsein [5 ]
机构：
[1] Chang Gung Mem Hosp, Dept Neurosurg, Chiayi 61363, Taiwan
[2] Chang Gung Univ, Coll Med, Tao Yuan 33302, Taiwan
[3] Chang Gung Mem Hosp, Dept Med Res, Chiayi 61363, Taiwan
[4] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[5] Natl Chiayi Univ, Coll Life Sci, Dept Microbiol Immunol & Biopharmaceut, Chiayi 60004, Taiwan
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2017年 / 2017卷
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED APOPTOSIS; CANCER CELLS; GLIOBLASTOMA; MIGRATION; INVASION; ENHANCEMENT; ACTIVATION; EXPRESSION; ACID;
D O I：
10.1155/2017/9489383
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZtreated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-.B pathway and possibly provide a novel prospective strategy for treating malignant glioma.
引用
收藏
页数：12
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