Successful treatment of metastatic fibrosarcomatous dermatofibrosarcoma protuberans with imatinib mesylate

被引:2
作者
Kambayashi, Yumi [1 ]
Kasahara, Yuki [2 ]
Ohuchi, Kentaro [1 ]
Amagai, Ryo [1 ]
Hashimoto, Akira [1 ]
Asano, Yoshihide [1 ]
Fujimura, Taku [1 ]
机构
[1] Tohoku Univ, Dept Dermatol, Grad Sch Med, Sendai, Miyagi, Japan
[2] Tohoku Univ Hosp, Dept Med Oncol, Sendai, Miyagi, Japan
关键词
CD34; fibrosarcomatous DFSP; imatinib mesylate; PD-L1; TRANSFORMATION;
D O I
10.1111/dth.15736
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor characterized by a high risk of local recurrence but a low risk of metastasis. A small subpopulation of DFSP undergoes fibrosarcomatous (FS) change, and approximately 15%-57% of cases of DFSP with FS change metastasizes, leading to a poor prognosis. In this report, a case of metastatic FS-DFSP that was successfully treated with imatinib mesylate in which the IHC staining pattern of recurrent DFSP was quantitatively analyzed in primary and metastatic DFSP areas, is described. Importantly, the recurrent area was composed of two IHC staining patterns (CD34(low) PD-L1(high) Ki67(high), and CD34(high) PD-L1(low) Ki67(low) pattern), while the metastatic area showed a clonal pattern (CD34(high) PD-L1(low) Ki67(intermediate)) in the present case. In this report, we described a case of metastatic fibrosarcomatous DFSP successfully treated with imatinib mesylate. This case suggests a subpopulation of DFSP with a favorable metastatic pattern.
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