Diversity-oriented approach to 1,2-dihydroisoquinolin-3(4H)-imines via copper(I)-catalyzed reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide and amine

被引:52
作者
Chen, Zhiyuan [2 ,3 ]
Ye, Chao [2 ,3 ]
Gao, Liang [2 ,3 ]
Wu, Jie [1 ]
机构
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China
[3] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
ONE-POT SYNTHESIS; CATALYZED MULTICOMPONENT REACTION; FRITSCH-BOBBITT SYNTHESIS; FACILE ACCESS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; TETRAHYDROISOQUINOLINE DERIVATIVES; SYNTHETIC UTILITY; RECENT PROGRESS; AMIDE SYNTHESIS;
D O I
10.1039/c1cc11176k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A three-component reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide, and amine catalyzed by copper(I) chloride (5 mol%), in the presence of triethylamine, under mild conditions is described. This transformation proceeds efficiently to generate 1,2-dihydroisoquinolin-3(4H)-imines in good to excellent yields.
引用
收藏
页码:5623 / 5625
页数:3
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