Live attenuated varicella vaccine

被引：66
作者：
Arvin, AM [1 ]
Gershon, AA [1 ]
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT PEDIAT, NEW YORK, NY 10032 USA
来源：
ANNUAL REVIEW OF MICROBIOLOGY | 1996年 / 50卷
关键词：
chicken pox; herpes zoster; immunization; shingles; latent virus infection; antiviral therapy;
D O I：
10.1146/annurev.micro.50.1.59
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Varicella-zoster virus (VZV) is a ubiquitous human pathogen that causes varicella, commonly called chicken pox; establishes latency; and reactivates as herpes tester, referred to as shingles. A live attenuated varicella vaccine, derived from the Oka strain of VZV has clinical efficacy for the prevention of varicella. The vaccine induces persistent immunity to VZV in healthy children and adults. Immunization against VZV also has the potential to lower the risk of reactivation of latent virus. The varicella vaccine may eventually reduce or eliminate herpes tester, which is a serious problem for elderly and immunocompromised individuals.
引用
收藏
页码：59 / 100
页数：42
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