New developments in the asymmetric Stetter reaction

被引：229

作者：

Christmann, M ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 18期

关键词：

asymmetric catalysis; carbenes; organocatalysis; Stetter reaction; umpolung;

D O I：

10.1002/anie.200500761

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Highly active carbene catalysts have revitalized the interest in the asymmetric Stetter reaction as a method for the construction of 1,4-dicarbonyl compounds. With the latest generation of a catalyst developed by Rovis and co-workers (1, for example), products with quaternary stereocenters such as 2 can be generated in 85% yield and 99% ee. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2632 / 2634

页数：3

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