Nitrergic neurons of the dorsal raphe nucleus encode information about stress duration

被引：4

作者：

Nichols, India S. ^{[1
,2
,3
]}

Jones, Mary I. ^{[1
]}

Okere, Chuma ^{[1
]}

Ananaba, Godwin ^{[1
]}

Bush, Brittany ^{[2
]}

Gray, Cloe ^{[2
]}

Brager, Allison ^{[2
,4
]}

Ehlen, J. Christopher ^{[2
]}

Paul, Ketema ^{[2
,3
]}

机构：

[1] Clark Atlanta Univ, Dept Biol Sci, Atlanta, GA 30314 USA

[2] Morehouse Sch Med, Dept Neurobiol, Atlanta, GA 30310 USA

[3] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA

[4] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA

来源：

PLOS ONE | 2017年 / 12卷 / 11期

关键词：

NITRIC-OXIDE SYNTHASE; DORSOLATERAL PERIAQUEDUCTAL GRAY; CENTRAL-NERVOUS-SYSTEM; NADPH-DIAPHORASE; NONSYNAPTIC COMMUNICATION; RAT-BRAIN; MODELS; EXPRESSION; EXPOSURE; ANXIETY;

D O I：

10.1371/journal.pone.0187071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitrergic neurons of the dorsal raphe nucleus (DRN) may play a role in physiological stress responses. The caudal lateral wings (CLW) are unique compared to other rostral-caudal DRN sub-regions because they contain distinct nitric oxide (NO) synthase (NOS) populations that are independent of tryptophan hydroxylase (TPH). NOS neurons in the CLW are also highly activated during acute restraint stress. However, the effects of acute stress duration on NOS activation in the CLW are unclear. Here NADPH-d, an index of NOS activity, is used to show that sub-regions of the DRN have differential NOS activation in response to 6 hours of restraint stress in rats. We report increased NOS activity through 6 hours of restraint in the caudal lateral wings and ventromedial sub-regions. These data suggest that, NOS neurons may play a dynamic role in the response to stress duration.

引用

页数：15

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