Single-molecule fluorescence spectroscopy of protein folding

被引：124

作者：

Schuler, B ^{[1
]}

机构：

[1] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland

来源：

CHEMPHYSCHEM | 2005年 / 6卷 / 07期

关键词：

emission spectroscopy; FRET (fluorescence resonance energy transfer); protein folding; proteins; single-molecule studies;

D O I：

10.1002/cphc.200400609

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Single-molecule spectroscopy is an important new approach for studying the intrinsically heterogeneous process of protein folding. This Review illustrates how different single-molecule fluorescence techniques have improved our understanding of mechanistic aspects in protein folding, exemplified by a series of recent experiments on a small protein.

引用

页码：1206 / 1220

页数：15

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