Uridine triphosphate (UTP) is released during cardiac ischemia

被引:41
作者
Erlinge, D [1 ]
Harnek, J
van Heusden, C
Olivecrona, G
Jern, S
Lazarowski, E
机构
[1] Univ Lund Hosp, Dept Cardiol, S-22185 Lund, Sweden
[2] Univ Lund Hosp, Thorac Radiol Heart & Lung Div, S-22185 Lund, Sweden
[3] Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC USA
[4] Univ Gothenburg, Sahlgrens Univ Hosp Ostra, Clin Expt Res Lab, Gothenburg, Sweden
关键词
uridine triphosphate; nucleotide; adenosine triphosphate; coronary circulation; arrhythmia; heart;
D O I
10.1016/j.ijcard.2004.10.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Extracellular uridine triphosphate (UTP) stimulates vasodilatation, automaticity in ventricular myocytes and release of tissue-plasminogen activator (t-PA), indicating that UTP may be important in cardiac regulation. We took advantage of a recently developed quantitative assay for UTP to test the hypothesis that UTP is released in the circulation during cardiac ischemia. Methods: In ten pigs, a balloon catheter in the left anterior descending artery was introduced to induce ischemia. Samples were collected from the coronary sinus. Blood flow in the coronary sinus was assessed by a Doppler velocity transducer. Results: Plasma UTP levels increased early during ischemia and early after reperfusion (by 257 +/- 100 and 247 +/- 72%, p < 0.05). Cardiac blood flow, ventricular arrhythmias and t-PA release were markedly increased at the same time points. In contrast, after 30 min, a second period of ischemia did not result in any significant increase of UTP or blood flow. Furthermore, ventricular arrhythmias were less frequent. UTP levels correlated with ventricular arrhythmia and blood flow. Similar results were found for ATP. Conclusion: For the first time we have shown that UTP is released during cardiac ischemia. UTP released during ischemia may stimulate blood flow, arrhythmia and t-PA release. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:427 / 433
页数:7
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