View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?

被引：10
作者：
Alamri, Abdulaziz [1 ]
Gounni, Abdelilah Soussi [1 ]
Kung, Sam K. P. [1 ]
机构：
[1] Univ Manitoba, Rady Fac Hlth Sci, Dept Immunol, Max Rady Coll Med, Winnipeg, MB R3E 0T5, Canada
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期
基金：
加拿大自然科学与工程研究理事会;
关键词：
semaphorins; semaphorin-3E; plexins; nervous system; cardiovascular; allergic asthma; cancer; natural killer cells; INNATE LYMPHOID-CELLS; INTRACELLULAR BACTERIAL-INFECTION; DENDRITIC CELLS; NK CELLS; CARDIOVASCULAR DEVELOPMENT; CHEMOREPULSIVE ACTIVITY; CANCER-IMMUNOTHERAPY; AXONAL GUIDANCE; IN-VIVO; 3E;
D O I：
10.3390/ijms18112337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma. We further speculate possible immune modulatory function(s) of Sema-3E on natural killer (NK) cells.
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页数：10
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