View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?

被引：10

作者：

Alamri, Abdulaziz ^{[1
]}

Gounni, Abdelilah Soussi ^{[1
]}

Kung, Sam K. P. ^{[1
]}

机构：

[1] Univ Manitoba, Rady Fac Hlth Sci, Dept Immunol, Max Rady Coll Med, Winnipeg, MB R3E 0T5, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

semaphorins; semaphorin-3E; plexins; nervous system; cardiovascular; allergic asthma; cancer; natural killer cells; INNATE LYMPHOID-CELLS; INTRACELLULAR BACTERIAL-INFECTION; DENDRITIC CELLS; NK CELLS; CARDIOVASCULAR DEVELOPMENT; CHEMOREPULSIVE ACTIVITY; CANCER-IMMUNOTHERAPY; AXONAL GUIDANCE; IN-VIVO; 3E;

D O I：

10.3390/ijms18112337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma. We further speculate possible immune modulatory function(s) of Sema-3E on natural killer (NK) cells.

引用

页数：10

共 78 条

[1] The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing [J].

Adams, RH ;

Lohrum, M ;

Klostermann, A ;

Betz, H ;

Puschel, AW .

EMBO JOURNAL, 1997, 16 (20) :6077-6086

[2]

Alamri A., 2017, COMMUNICATION

[3] Functional interactions between dendritic cells and NK cells during viral infection [J].

Andrews, DM ;

Scalzo, AA ;

Yokoyama, WM ;

Smyth, MJ ;

Degli-Esposti, MA .

NATURE IMMUNOLOGY, 2003, 4 (02) :175-181

[4] A Role for Class 3 Semaphorins in Prostate Cancer [J].

Blanc, V. ;

Nariculam, J. ;

Munson, P. ;

Freeman, A. ;

Klocker, H. ;

Masters, J. ;

Williamson, M. .

PROSTATE, 2011, 71 (06) :649-658

[5] Engineering Dendritic Cells to Enhance Cancer Immunotherapy [J].

Boudreau, Jeanette E. ;

Bonehill, Aude ;

Thielemans, Kris ;

Wan, Yonghong .

MOLECULAR THERAPY, 2011, 19 (05) :841-853

[6] Natural killer cell biology: An update and future directions [J].

Campbell, Kerry S. ;

Hasegawa, Jun .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (03) :536-544

[7] Semaphorin signaling in cancer cells and in cells of the tumor microenvironment - two sides of a coin [J].

Capparuccia, Lorena ;

Tamagnone, Luca .

JOURNAL OF CELL SCIENCE, 2009, 122 (11) :1723-1736

[8] Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform [J].

Casazza, Andrea ;

Kigel, Boaz ;

Maione, Federica ;

Capparuccia, Lorena ;

Kessler, Ofra ;

Giraudo, Enrico ;

Mazzone, Massimiliano ;

Neufeld, Gera ;

Tamagnone, Luca .

EMBO MOLECULAR MEDICINE, 2012, 4 (03) :234-250

[9] Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice [J].

Casazza, Andrea ;

Finisguerra, Veronica ;

Capparuccia, Lorena ;

Camperi, Andrea ;

Swiercz, Jakub M. ;

Rizzolio, Sabrina ;

Rolny, Charlotte ;

Christensen, Claus ;

Bertotti, Andrea ;

Sarotto, Ivana ;

Risio, Mauro ;

Trusolino, Livio ;

Weitz, Jurgen ;

Schneider, Martin ;

Mazzone, Massimilano ;

Comoglio, Paolo M. ;

Tamagnone, Luca .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (08) :2684-2698

[10] Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance [J].

Castellani, V ;

Chédotal, A ;

Schachner, M ;

Faivre-Sarrailh, C ;

Rougon, G .

NEURON, 2000, 27 (02) :237-249

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