Gender and the progression of renal disease

被引:109
作者
Seliger, SL
Davis, C
Stehman-Breen, C
机构
[1] VA Puget Sound Hlth Care Syst, Renal Unit, Seattle, WA 98108 USA
[2] Univ Washington, Med Ctr, Div Nephrol, Seattle, WA 98195 USA
[3] Univ Washington, Med Ctr, Kidney Pancreas Transplant Program, Seattle, WA 98195 USA
关键词
D O I
10.1097/00041552-200103000-00010
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Many studies of chronic renal disease have reported that men have a more rapid progression of renal insufficiency. However, other studies have found no differences between the sexes, and the true effect of sex on chronic renal disease remains a topic of controversy. There is evidence that women with non-diabetic renal diseases experience a slower progression, but in diabetic renal disease, the effect of gender is not yet established. Sex hormones may mediate the effects of gender on chronic renal disease, through alterations in the renin-angiotensin system, reduction in mesangial collagen synthesis, the modification of collagen degradation, and upregulation of nitric oxide synthesis. Curr Opin Nephrol Hypertens 10:219-225. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:219 / 225
页数:7
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