Unexpected overdose blood concentration of tacrolimus: Keep in mind the role of inflammation

被引：15

作者：

Bonneville, Edouard ^{[1
]}

Gautier-Veyret, Elodie ^{[1
,2
]}

Ihl, Cordelia ^{[3
]}

Hilleret, Marie-Noelle ^{[4
]}

Baudrant, Magalie ^{[3
]}

Fonrose, Xavier ^{[1
]}

Stanke-Labesque, Francoise ^{[1
,2
]}

机构：

[1] CHU, Lab Pharmacol Pharmacogenet Toxicol, Pole Biol & Pathol, Grenoble, Alpes, France

[2] Univ Grenoble Alpes, HP2, CHU Grenoble Alpes, INSERM, F-38000 Grenoble, France

[3] CHU, Pole Pharm, Grenoble, Alpes, France

[4] CHU, Dept Hepatogastroenterol, Grenoble, Alpes, France

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2020年 / 86卷 / 09期

关键词：

clinical pharmacology; drug safety; inflammation; therapeutic drug monitoring;

D O I：

10.1111/bcp.14292

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tacrolimus is the cornerstone of the therapeutic immunosuppressive strategy in liver transplantation. The inter-individual and intra-individual variability of its trough blood concentrations is a surrogated biomarker of allograft rejection. Here we described two cases of patients with liver transplant who exhibited increases of tacrolimus blood trough concentration adjusted on the dose while experiencing acute inflammatory episodes. These case reports highlight the inhibitory effect of acute inflammation on tacrolimus metabolism and show that it accounts for the longitudinal intra-individual variability of tacrolimus blood concentrations, beyond drug-drug interaction and observance.

引用

页码：1888 / 1891

页数：4

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