Structural hybridization of bimetallic zeolitic imidazolate framework (ZIF) nanosheets and carbon nanofibers for efficiently sensing α-synuclein oligomers

被引:107
作者
Guo, Chuanpan [1 ,2 ]
Hu, Mengyao [1 ]
Li, Zhenzhen [1 ]
Duan, Fenghe [1 ,2 ]
He, Linghao [1 ]
Zhang, Zhihong [1 ]
Marchetti, Fabio [2 ]
Du, Miao [1 ]
机构
[1] Zhengzhou Univ Light Ind, Henan Prov Key Lab Surface & Interface Sci, Zhengzhou 450002, Peoples R China
[2] Univ Camerino, Chem Sect, Sch Sci & Technol, Via S Agostino 1, I-62032 Camerino, MC, Italy
基金
中国国家自然科学基金;
关键词
Bimetallic zeolitic imidazolate frameworks; 1D/2D structural nanohybrids; Carbon nanofibers; alpha-Synuclein oligomers detection; Electrochemical aptasensor; ELECTROCHEMICAL APTASENSOR; SENSITIVE DETECTION; SELECTIVE DETECTION; PARKINSONS-DISEASE; OXYGEN EVOLUTION; GRAPHENE OXIDE; NANOPARTICLES; IMMUNOSENSOR; SURFACE; WATER;
D O I
10.1016/j.snb.2020.127821
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A high-efficiency sensing system for alpha-synuclein (alpha-Syn) oligomers was designed based on a novel one dimensional (1D)/2D structural nanohybrid (denoted as CoMnZIF@CNF) of CoMn-based zeolitic imidazolate framework nanosheets (CoMnZIF NSs) vertically grown around carbon nanofibers (CNFs). CNFs were prepared by calcining electrospun polyacrylonitrile under Ar/H-2 atmosphere and used as the template for CoMnZIF synthesis, which can remarkably enlarge the electrochemical signal of the CoMnZIF@CNF nanohybrid. The series of CoMnZIF@CNF nanohybrids were modulated by changing the ratios of precursors Co(NO3)(2) and Mn(NO3)(2) (i.e. 3:1, 1:1, and 1:3), leading to optimized sensing performances of alpha-Syn oligomers. Owing to the hierarchical nanostructure, good biocompatibility, and strong bioaffinity, the alpha-Syn oligomer aptamer can be strongly anchored over the CoMnZIF@CNF nanohybrid. Although the three CoMnZIF@CNF nanohybrids show comparable electrochemical activity, the CoMnZIF@CNF(1-3)-based aptasensor exhibits the superior sensing performance to other CoMnZIF@CNF nanohybrids and reported MOFs, giving a low detection limit of 0.87 fg mL(-1) (45.7 fM) within the concentration of alpha-Syn oligomers rangefrom 1 fg mL(-1) (52.6 fM) to 0.2 ng mL(-1) (0.1 nM). The aptasensor based on CoMnZIF@CNF also has excellent selectivity, stability, reproducibility, and usability for the detection of alpha-Syn oligomersin human serum. The efficient strategy of structural hybridization can be used in designing different aptasensors and further extend the application range of ZIFs materials.
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页数:11
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