The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

被引：14

作者：

Zhang, Q. -G. ^{[1
]}

Wei, F. ^{[1
,2
]}

Liu, Q. ^{[1
]}

Chen, L. -J. ^{[1
]}

Liu, Y. -Y. ^{[1
]}

Luo, F. ^{[1
]}

Xiong, H. -R. ^{[1
]}

Yang, Z. -Q. ^{[1
]}

机构：

[1] Wuhan Univ, State Key Lab Virol, Natl Lab Antiviral & Tumor Tradit Chinese Med, Inst Med Virol,Res Ctr Food & Drug Evaluat,Sch Me, Wuhan 430071, Peoples R China

[2] Hubei Univ Chinese Med, Sch Basic Med, Wuhan 430065, Peoples R China

来源：

ACTA VIROLOGICA | 2014年 / 58卷 / 04期

关键词：

herpes simplex virus 1; flavonoid; Polygonum perfoliatum L; antiviral; Hep-2; cell; mouse; IN-VITRO; TYPE-1;

D O I：

10.4149/av_2014_04_368

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.

引用

页码：368 / 373

页数：6

共 18 条

[1] (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry [J].

Calland, Noemie ;

Albecka, Anna ;

Belouzard, Sandrine ;

Wychowski, Czeslaw ;

Duverlie, Gilles ;

Descamps, Veronique ;

Hober, Didier ;

Dubuisson, Jean ;

Rouille, Yves ;

Seron, Karin .

HEPATOLOGY, 2012, 55 (03) :720-729

[2] Free-radical-scavenging and antioxidant activities of secondary metabolites from reddened Cv. Annurca apple fruits [J].

Cefarelli, G ;

D'Abrosca, B ;

Fiorentino, A ;

Izzo, A ;

Mastellone, C ;

Pacifico, S ;

Piscopo, V .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (03) :803-809

[3]

Cheng Huan-Bo, 2012, Zhong Yao Cai, V35, P1088

[4] Structure-Activity Relationship Study of Biflavonoids on the Dengue Virus Polymerase DENV-NS5 RdRp [J].

Coulerie, Paul ;

Nour, Mohammed ;

Maciuk, Alexandre ;

Eydoux, Cecilia ;

Guillemot, Jean-Claude ;

Lebouvier, Nicolas ;

Hnawia, Edouard ;

Leblanc, Karine ;

Lewin, Guy ;

Canard, Bruno ;

Figadere, Bruno .

PLANTA MEDICA, 2013, 79 (14) :1313-1318

[5]

Emmert DH, 2000, AM FAM PHYSICIAN, V61, P1697

[6] Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L. [J].

Fan, Dongsheng ;

Zhou, Xin ;

Zhao, Chao ;

Chen, Huaguo ;

Zhao, Yang ;

Gong, Xiaojian .

FITOTERAPIA, 2011, 82 (06) :805-810

[7] In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1 [J].

Gonçalves, JLS ;

Leitao, SG ;

Delle Monache, F ;

Miranda, MMFS ;

Santos, MGM ;

Romanos, MTV ;

Wigg, MD .

PHYTOMEDICINE, 2001, 8 (06) :477-480

[8] In vitro and in vivo evaluation of a novel antiherpetic flavonoid, 4'-phenylflavone, and its synergistic actions with acyclovir [J].

Hayashi, Kyoko ;

Iinuma, Munekazu ;

Sasaki, Kohei ;

Hayashi, Toshimitsu .

ARCHIVES OF VIROLOGY, 2012, 157 (08) :1489-1498

[9] Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges [J].

Holmgren, J ;

Czerkinsky, C ;

Eriksson, K ;

Mharandi, A .

VACCINE, 2003, 21 :S89-S95

[10] Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus [J].

Isaacs, Charles E. ;

Wen, Guang Y. ;

Xu, Weimin ;

Jia, Jun Hua ;

Rohan, Lisa ;

Corbo, Christopher ;

Di Maggio, Vincenzo ;

Jenkins, Edmund C., Jr. ;

Hillier, Sharon .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (03) :962-970

← 1 2 →