Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men

被引：177
作者：
Mullington, JM
Chan, JL
Van Dongen, HPA
Szuba, MP
Samaras, J
Price, NJ
Meier-Ewert, HK
Dinges, DF
Mantzoros, CS
机构：
[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Lahey Clin Fdn, Boston, MA USA
[4] Tufts Med Sch, Boston, MA USA
[5] Univ Penn, Sch Med, Dept Psychiat, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA
[6] Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2003年 / 15卷 / 09期
关键词：
sleep deprivation; leptin; diurnal rhythm;
D O I：
10.1046/j.1365-2826.2003.01069.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
引用
收藏
页码：851 / 854
页数：4
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