Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men

被引：174
作者：
Mullington, JM
Chan, JL
Van Dongen, HPA
Szuba, MP
Samaras, J
Price, NJ
Meier-Ewert, HK
Dinges, DF
Mantzoros, CS
机构：
[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Lahey Clin Fdn, Boston, MA USA
[4] Tufts Med Sch, Boston, MA USA
[5] Univ Penn, Sch Med, Dept Psychiat, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA
[6] Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2003年 / 15卷 / 09期
关键词：
sleep deprivation; leptin; diurnal rhythm;
D O I：
10.1046/j.1365-2826.2003.01069.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
引用
收藏
页码：851 / 854
页数：4
相关论文
共 50 条
  • [31] Serum leptin level in healthy sedentary young men after a short-term exercise
    Kishali, Necip Fazil
    [J]. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 5 (04): : 522 - 526
  • [32] Partial sleep restriction modulates secretory activity of thyrotropic axis in healthy men
    Schmid, Sebastian M.
    Hallschmid, Manfred
    Jauch-Chara, Kamila
    Kueck, Mareike C.
    Lehnert, Hendrik
    Schultes, Bernd
    [J]. JOURNAL OF SLEEP RESEARCH, 2013, 22 (02) : 166 - 169
  • [33] Sleep extension increases IGF-I concentrations before and during sleep deprivation in healthy young men
    Chennaoui, Mounir
    Arnal, Pierrick J.
    Drogou, Catherine
    Sauvet, Fabien
    Gomez-Merino, Danielle
    [J]. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2016, 41 (09) : 963 - 970
  • [34] Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men
    Mantzoros, CS
    Liolios, AD
    Tritos, NA
    Kaklamani, VG
    Doulgerakis, DE
    Griveas, I
    Moses, AC
    Flier, JS
    [J]. OBESITY RESEARCH, 1998, 6 (03): : 179 - 186
  • [35] Short-term biological variation and diurnal rhythm of cardiac troponin I (Access hs-TnI) in healthy subjects
    Zaninotto, Martina
    Padoan, Andrea
    Mion, Monica Maria
    Marinova, Mariela
    Plebani, Mario
    [J]. CLINICA CHIMICA ACTA, 2020, 504 : 163 - 167
  • [36] Circulating follistatin displays a day-night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans
    Anastasilakis, Athanasios D.
    Polyzos, Stergios A.
    Skouvaklidou, Elpida C.
    Kynigopoulos, Georgios
    Saridakis, Zacharias G.
    Apostolou, Aggeliki
    Triantafyllou, Georgios A.
    Karagiozoglou-Lampoudi, Thomai
    Mantzoros, Christos S.
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (10): : 1459 - 1465
  • [37] Diurnal variation of pulse wave velocity assessed non-invasively by applanation tonometry in young healthy men
    Bodlaj, Gerd
    Berg, Joerg
    Biesenbach, Georg
    [J]. YONSEI MEDICAL JOURNAL, 2007, 48 (04) : 665 - 670
  • [38] DIURNAL CHANGES IN PLASMA-LIPOPROTEINS OF FREE-LIVING HEALTHY-MEN CONSUMING A STANDARD DIET
    FAINARU, M
    SCHAFER, Z
    GAVISH, D
    SKURNIK, Y
    ARGOV, R
    KAPLAN, S
    [J]. ISRAEL JOURNAL OF MEDICAL SCIENCES, 1994, 30 (01): : 83 - 89
  • [39] Diurnal variation of arterial stiffness and subendocardial perfusion noninvasively assessed using applanation tonometry in healthy young men
    Bodlaj, G
    Berg, J
    Biesenbach, G
    [J]. WIENER KLINISCHE WOCHENSCHRIFT, 2005, 117 (9-10) : 348 - 352
  • [40] Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin
    Paleczny, Bartlomiej
    Siennicka, Agnieszka
    Zacharski, Maciej
    Jankowska, Ewa Anita
    Ponikowska, Beata
    Ponikowski, Piotr
    [J]. CLINICAL AUTONOMIC RESEARCH, 2016, 26 (02) : 107 - 116
12345