Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men

被引:177
作者
Mullington, JM
Chan, JL
Van Dongen, HPA
Szuba, MP
Samaras, J
Price, NJ
Meier-Ewert, HK
Dinges, DF
Mantzoros, CS
机构
[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Lahey Clin Fdn, Boston, MA USA
[4] Tufts Med Sch, Boston, MA USA
[5] Univ Penn, Sch Med, Dept Psychiat, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA
[6] Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA
关键词
sleep deprivation; leptin; diurnal rhythm;
D O I
10.1046/j.1365-2826.2003.01069.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
引用
收藏
页码:851 / 854
页数:4
相关论文
共 50 条
[21]   Acute hyperinsulinemia reduces plasma leptin levels in insulin-sensitive Japanese men [J].
Masuo, K ;
Katsuya, T ;
Ogihara, T ;
Tuck, ML .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (02) :235-243
[22]   DIURNAL RHYTHM IN SERUM OSTEOCALCIN - RELATION WITH SLEEP, GROWTH-HORMONE, AND PTH(1-84) [J].
NIELSEN, HK ;
BRIXEN, K ;
KASSEM, M ;
CHRISTENSEN, SE ;
MOSEKILDE, L .
CALCIFIED TISSUE INTERNATIONAL, 1991, 49 (06) :373-377
[23]   Food deprivation reduces and leptin increases the amplitude of an active sensory and communication signal in a weakly electric fish [J].
Sinnett, Philip M. ;
Markham, Michael R. .
HORMONES AND BEHAVIOR, 2015, 71 :31-40
[24]   Enhancing Slow Wave Sleep with Sodium Oxybate Reduces the Behavioral and Physiological Impact of Sleep Loss [J].
Walsh, James K. ;
Hall-Porter, Janine M. ;
Griffin, Kara S. ;
Dodson, Ehren R. ;
Forst, Elizabeth H. ;
Curry, Denise T. ;
Eisenstein, Rhody D. ;
Schweitzer, Paula K. .
SLEEP, 2010, 33 (09) :1217-1225
[25]   Effects of sleep restriction periods on serum cortisol levels in healthy men [J].
Wu, Huijuan ;
Zhao, Zhongxin ;
Stone, William S. ;
Huang, Liuqing ;
Zhuang, Jianhua ;
He, Bin ;
Zhang, Peng ;
Li, Yanpeng .
BRAIN RESEARCH BULLETIN, 2008, 77 (05) :241-245
[26]   Longitudinal stability of the diurnal rhythm of intraocular pressure in subjects with healthy eyes, ocular hypertension and pigment dispersion syndrome [J].
Huchzermeyer, Cord ;
Reulbach, Udo ;
Horn, Folkert ;
Laemmer, Robert ;
Mardin, Christian Y. ;
Juenemann, Anselm G. M. .
BMC OPHTHALMOLOGY, 2014, 14
[27]   Longitudinal stability of the diurnal rhythm of intraocular pressure in subjects with healthy eyes, ocular hypertension and pigment dispersion syndrome [J].
Cord Huchzermeyer ;
Udo Reulbach ;
Folkert Horn ;
Robert Lämmer ;
Christian Y Mardin ;
Anselm GM Jünemann .
BMC Ophthalmology, 14
[28]   Altered Percent Amplitude of Fluctuation in Healthy Subjects After 36 h Sleep Deprivation [J].
Zeng, Bingliang ;
Zhou, Jian ;
Li, Zicong ;
Zhang, Hua ;
Li, Zongliang ;
Yu, Peng .
FRONTIERS IN NEUROLOGY, 2021, 11
[29]   Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women [J].
Sandoval, DA ;
Galassetti, P ;
Tate, D ;
Neill, A ;
Davis, SN .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2003, 17 (06) :301-306
[30]   Serum leptin level in healthy sedentary young men after a short-term exercise [J].
Kishali, Necip Fazil .
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 5 (04) :522-526