Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding potential strategies

被引:137
作者
Xu, Helin [1 ]
Yao, Qing [1 ]
Cai, Cuifang [1 ]
Gou, Jinxin [1 ]
Zhang, Yu [1 ]
Zhong, Haijun [2 ]
Tang, Xing [1 ]
机构
[1] Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 110016, Liaoning, Peoples R China
[2] Nanchang Univ, Coll Pharm, Dept Pharmaceut, Nanchang 330006, Jiangxi, Peoples R China
关键词
Micelle; Amphiphilic poly(amino acid); Poly(glutamic acid); Poly(aspartic acid); Non-covalent interaction; Drug-polymer conjugate; Stability; BLOCK-COPOLYMER MICELLES; POLYION COMPLEX MICELLES; POLYMERIC ANTICANCER DRUG; ANTITUMOR-ACTIVITY; PHYSICOCHEMICAL PROPERTIES; POLY(L-AMINO ACIDS); PIC MICELLES; PLASMID DNA; IONIC CORES; AMINO-ACID;
D O I
10.1016/j.jconrel.2014.12.012
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Core-shell structured micelles produced from an amphiphilic block copolymer are promising drug delivery vehicles because their hydrophobic core can encapsulate hydrophobic drugs through hydrophobic interactions and their hydrophilic shell can prolong their circulation in the blood. However, the low cargo capacity and the lack of stability in the blood are major problems associated with micellar drug delivery systems. Poly(amino acid) or its derivatives, especially poly(glutamic acid) or poly(aspartic acid) or poly(L-lysine), are widely used as micelle-forming materials because of their remarkable advantages such as easy biodegradability, good biocompatibility and availability of side functional groups. In this review, the structures, synthesis and characteristics of the amphiphilic poly(amino acid) based micelles are initially described, then the driving forces, which may determine the drug loading capacity, and the variants which affect the stability of drug-loaded micelles in blood post-injection are summarized. Furthermore, the strategies for increasing the drug loading capacity and improve the stability in blood are also described. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:84 / 97
页数:14
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