In Vivo Toxicity Assessment of Laminarin Based Silver Nanoparticles from Turbinaria ornata in Adult Zebrafish (Danio rerio)

被引：5
作者：
Renuka, Remya Rajan [1 ]
Ravindranath, Radhika Rajasree Santha [1 ,4 ]
Raguraman, Vasantharaja [1 ]
Yoganandham, Suman Thodhal [1 ,2 ,3 ]
Kasivelu, Govindaraju [1 ]
Lakshminarayanan, Aranganathan [1 ]
机构：
[1] Sathyabama Inst Sci & Technol, Ctr Ocean Res, Rajiv Gandhi Rd, Chennai 600119, Tamil Nadu, India
[2] Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China
[3] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
[4] KUFOS, Dept Fish Proc Technol, Panangad Rd, Cochin 682506, Kerala, India
来源：
JOURNAL OF CLUSTER SCIENCE | 2020年 / 31卷 / 01期
关键词：
Laminarin; Silver nanoparticles; Toxicity; Turbinaria ornata; ICP-OES; Zebrafish (Danio rerio); OXIDATIVE STRESS; CYTOTOXICITY; NANOMATERIALS; EXPOSURE;
D O I：
10.1007/s10876-019-01632-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Silver nanoparticles synthesized using laminarin from Turbinaria ornata were subjected to acute toxicity in adult zebrafish. LC50 concentration of L-AgNPs and C-AgNPs at 96 h was noted to be 25.22 and 19.93 mg/L. To find out the fundamental toxicity mechanisms of L-AgNPs and C-AgNPs, the half of LC50 concentration 12.61 and 9.96 mg/L was exposed to adult zebrafish for 14 days respectively. There are no cytological changes in L-AgNPs whereas cytological changes were observed in gills, brain and liver tissues of C-AgNPs. The results concluded a plausible symbol for oxidative stress in zebrafish. The activities of antioxidant enzyme superoxide dismutase, catalase and glutathione peroxidase were decreased significantly in the C-AgNPs exposed while L-AgNPs showed no significant difference when compared to control. ICP-OES analysis of gills, liver and brain demonstrated that L-AgNPs and C-AgNPs revelation for 14 days resulted in enhanced silver uptake compared to fish treated with control are discussed in detail.
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收藏
页码：185 / 195
页数：11
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