An Older Subjective Age Is Related to Accelerated Epigenetic Aging

被引：15

作者：

Stephan, Yannick ^{[1
]}

Sutin, Angelina R. ^{[2
]}

Luchetti, Martina ^{[2
]}

Terracciano, Antonio ^{[3
]}

机构：

[1] Univ Montpellier, Euromov, Montpellier, France

[2] Florida State Univ, Dept Behav Sci & Social Med, Coll Med, Tallahassee, FL 32306 USA

[3] Florida State Univ, Coll Med, Dept Geriatr, Tallahassee, FL 32306 USA

来源：

PSYCHOLOGY AND AGING | 2021年 / 36卷 / 06期

关键词：

subjective age; epigenetic clock; inflammation; self-rated health; DNA methylation; LIFE; HEALTH; CLOCK;

D O I：

10.1037/pag0000607

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles.

引用

页码：767 / 772

页数：6

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