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Evaluation of Hepatitis B screening and reactivation in patients receiving rituximab containing chemotherapy: A single-centre study
被引:5
作者:

Bozkurt, Ilkay
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h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey

Cerik, Hatun Ozturk
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h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey

Kir, Seher
论文数: 0 引用数: 0
h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Internal Med, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey

Ustaoglu, Muge
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h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Gastroenterol, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey

Turgut, Mehmet
论文数: 0 引用数: 0
h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Hematol, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey

Esen, Saban
论文数: 0 引用数: 0
h-index: 0
机构:
Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey
机构:
[1] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis, Samsun, Turkey
[2] Ondokuz Mayis Univ, Sch Med, Dept Internal Med, Samsun, Turkey
[3] Ondokuz Mayis Univ, Sch Med, Dept Gastroenterol, Samsun, Turkey
[4] Ondokuz Mayis Univ, Sch Med, Dept Hematol, Samsun, Turkey
关键词:
HEMATOLOGICAL MALIGNANCIES;
VIRUS REACTIVATION;
MANAGEMENT;
LYMPHOMA;
THERAPY;
ANTIBODY;
RISK;
D O I:
10.1111/ijcp.14685
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aims Hepatitis B virus (HBV) infection is a worldwide distributing viral disease. Hepatitis caused by HBV reactivation may progress to chronic illness and associated with increased risk of hepatic failure and hepatocellular cancer. Rituximab (RTX) is an immunosuppressive agent, is particularly used in the treatment of non-Hodgkin's Lymphoma. Patients have significant risk for HBV reactivation following chemotherapy with a RTX-containing regimen. This study aimed to determine the HBV screening manner and reactivation rates in patients with haematological neoplasm following chemotherapy including Rituximab. Methods This is a single-centered retrospective cohort study. A total of 331 adults with haematological disorders who received chemotherapy regimen including RTX between years of 2006 and 2016 were enrolled. Patients who experienced reactivation were evaluated. Results Only 130 of 331 patients were screened appropriately for HBV infection for 10-year period. We found 18 patients were Hepatitis B surface antigen (HBsAg) (+) and 16 (88.8%) of them received antiviral prophylaxis. Among screened patients, 27 were HBsAg (-)/AntiHBc (+) and only 10 (37%) of them received HBV prophylaxis. In total, nine patients experienced reactivation, six were from screened and three were from unscreened group. Conclusion Incomplete screening and inappropriate prophylaxis may result in HBV reactivation in patients under RTX-based chemotherapy and related complications such as death.
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