New roles for the LKB1→AMPK pathway

被引：217

作者：

Hardie, DG ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Div Mol Physiol, Dundee DD1 4HN, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.ceb.2005.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The AMP-activated protein kinase(AMPK) is a sensor of cellular energy that is conserved throughout eukaryotes. It is activated by rising AMP, signifying falling energy status caused by starvation for a carbon source or other stress. Binding of AMP to the regulatory gamma subunit triggers phosphorylation of the catalytic a subunit by the upstream kinase LKB1, and the activated kinase switches on ATP-generating catabolic pathways while switching off ATP-requiring processes. AMPK inhibits the TOR (target of rapamycin) pathway by phosphorylating TSC2, thus inhibiting cell growth during times of stress. AMPK is also a target for adipokines that regulate energy balance at the whole-body level.

引用

页码：167 / 173

页数：7

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