A new opening for orally taken peptide drugs

被引：12

作者：

Artursson, Per ^{[1
,2
]}

Lundquist, Patrik ^{[1
]}

机构：

[1] Uppsala Univ, Dept Pharm, Uppsala, Sweden

[2] Uppsala Univ, Sci Life Lab, Uppsala, Sweden

来源：

NATURE BIOMEDICAL ENGINEERING | 2020年 / 4卷 / 01期

基金：

美国国家科学基金会;

关键词：

ABSORPTION;

D O I：

10.1038/s41551-019-0513-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.

引用

页码：12 / 13

页数：2

共 15 条

[1] An ingestible self-orienting system for oral delivery of macromolecules [J].

Abramson, Alex ;

Caffarel-Salvador, Ester ;

Khang, Minsoo ;

Dellal, David ;

Silverstein, David ;

Gao, Yuan ;

Frederiksen, Morten Revsgaard ;

Vegge, Andreas ;

Hubalek, Frantisek ;

Water, Jorrit J. ;

Friderichsen, Anders V. ;

Fels, Johannes ;

Kirk, Rikke Kaae ;

Cleveland, Cody ;

Collins, Joy ;

Tamang, Siddartha ;

Hayward, Alison ;

Landh, Tomas ;

Buckley, Stephen T. ;

Roxhed, Niclas ;

Rahbek, Ulrik ;

Langer, Robert ;

Traverso, Giovanni .

SCIENCE, 2019, 363 (6427) :611-+

[2] A luminal unfolding microneedle injector for oral delivery of macromolecules [J].

Abramson, Alex ;

Caffarel-Salvador, Ester ;

Soares, Vance ;

Minahan, Daniel ;

Tian, Ryan Yu ;

Lu, Xiaoya ;

Dellal, David ;

Gao, Yuan ;

Kim, Soyoung ;

Wainer, Jacob ;

Collins, Joy ;

Tamang, Siddartha ;

Hayward, Alison ;

Yoshitake, Tadayuki ;

Lee, Hsiang-Chieh ;

Fujimoto, James ;

Fels, Johannes ;

Frederiksen, Morten Revsgaard ;

Rahbek, Ulrik ;

Roxhed, Niclas ;

Langer, Robert ;

Traverso, Giovanni .

NATURE MEDICINE, 2019, 25 (10) :1512-+

[3] An intestinal paracellular pathway biased toward positively-charged macromolecules [J].

Almansour, Khaled ;

Taverner, Alistair ;

Turner, Jerrold R. ;

Eggleston, Ian M. ;

Mrsny, Randall J. .

JOURNAL OF CONTROLLED RELEASE, 2018, 288 :111-125

[4] Physiology and Function of the Tight Junction [J].

Anderson, James M. ;

Van Itallie, Christina M. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2009, 1 (02) :a002584

[5] Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease [J].

Buckley, Aaron ;

Turner, Jerrold R. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2018, 10 (01)

[6] Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist [J].

Buckley, Stephen T. ;

Baekdal, Tine A. ;

Vegge, Andreas ;

Maarbjerg, Stine J. ;

Pyke, Charles ;

Ahnfelt-Ronne, Jonas ;

Madsen, Kim G. ;

Scheele, Susanne G. ;

Alanentalo, Tomas ;

Kirk, Rikke K. ;

Pedersen, Betty L. ;

Skyggebjerg, Rikke B. ;

Benie, Andrew J. ;

Strauss, Holger M. ;

Wahlund, Per-Olof ;

Bjerregaard, Simon ;

Farkas, Erzsebet ;

Fekete, Csaba ;

Sondergaard, Flemming L. ;

Borregaard, Jeanett ;

Hartoft-Nielsen, Marie-Louise ;

Knudsen, Lotte Bjerre .

SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (467)

[7]

FDA, 2019, FDA APPR 1 OR GLP 1

[8] Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers [J].

Hubatsch, Ina ;

Ragnarsson, Eva G. E. ;

Artursson, Per .

NATURE PROTOCOLS, 2007, 2 (09) :2111-2119

[9] Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability [J].

Lamson, Nicholas G. ;

Berger, Adrian ;

Fein, Katherine C. ;

Whitehead, Kathryn A. .

NATURE BIOMEDICAL ENGINEERING, 2020, 4 (01) :84-96

[10] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues [J].

Lundquist, P. ;

Artursson, P. .

ADVANCED DRUG DELIVERY REVIEWS, 2016, 106 :256-276

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