Palladium-Catalyzed Controllable Reductive/Oxidative Heck Coupling between Cyclic Enones and Thiophenes via C-H Activation

被引：14

作者：

Wen, Zhen-Kang ^{[1
]}

Zhao, Ze-Kai ^{[1
]}

Wang, Ning-Jing ^{[1
]}

Chen, Zi-Ling ^{[1
]}

Chao, Jian-Bin ^{[2
]}

Feng, Li-Heng ^{[1
]}

机构：

[1] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China

[2] Shanxi Univ, Sci Instrument Ctr, Taiyuan 030006, Shanxi, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 23期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC CONJUGATE ADDITION; OXIDATIVE HECK; ARYLBORONIC ACIDS; ENANTIOSELECTIVE SYNTHESIS; BOND ACTIVATION; ARENES; FUNCTIONALIZATION; ALKENYLATION; OLEFINATION; HYDROARYLATION;

D O I：

10.1021/acs.orglett.9b03721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a straightforward, environmentally friendly, and controllable palladium/ligand catalytic system to enable reductive/oxidative Heck reactions of cyclic enones with thiophene or furan derivatives via C-H activation. The key to this tunable reaction is the appropriate intercepting thienyl-Pd(II)-enolate during the enolization process. Such a controllable and economic protocol would not only provide efficient methods to construct various value-added beta-heteroarylated cyclic ketones/enones but also shed light on developing other conjugate addition reactions via C-H activation.

引用

页码：9545 / 9549

页数：5

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