A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from β-oxo amides under Vilsmeier conditions

被引：71
作者：
Xiang, Dexuan [2 ]
Wang, Kewei [2 ]
Liang, Yongjiu [1 ]
Zhou, Guangyuan [1 ]
Dong, Dewen [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[2] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/ol702846t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
引用
收藏
页码：345 / 348
页数：4
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