New perspectives on the neurobiology of PTSD: High-resolution imaging of neural circuit (dys)function with magnetoencephalography

被引:2
作者
Dunkley, Benjamin T. [1 ,2 ,3 ]
Jetly, Rakesh [4 ]
Pang, Elizabeth W. [2 ,5 ]
Taylor, Margot J. [1 ,2 ,6 ]
机构
[1] Hosp Sick Children SickKids, Dept Diagnost Imaging, Toronto, ON, Canada
[2] Hosp Sick Children SickKids Res Inst, Neurosci & Mental Hlth, Toronto, ON, Canada
[3] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada
[4] Canadian Forces Hlth Serv Grp, Dept Natl Def, Ottawa, ON, Canada
[5] Hosp Sick Children SickKids, Div Neurol, Toronto, ON, Canada
[6] Univ Toronto, Dept Psychol, Toronto, ON, Canada
来源
JOURNAL OF MILITARY VETERAN AND FAMILY HEALTH | 2020年 / 6卷
关键词
brain dynamics; brain oscillations; functional brain imaging; functional connectivity; magnetoencephalography; NATO; neural circuits; PTSD; POSTTRAUMATIC-STRESS-DISORDER; TRANSCRANIAL MAGNETIC STIMULATION; NEUROCIRCUITRY MODELS; MENTAL-DISORDERS; CONNECTIVITY; PREVALENCE; VETERANS; DYNAMICS; FORCES;
D O I
10.3138/jmvfh.2019-0029
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Introduction: Combat-related posttraumatic stress disorder (PTSD) is increasingly conceptualized in psychiatry as a disorder of dysfunctional neural circuits. Advances in neuroimaging have enabled the study of those networks non-invasively. PTSD is currently assessed using subjective self-reporting to inform crucial decisions, such as fitness to deploy, but objective markers would aid in diagnosis and return-to-deployment decisions. Methods: Magnetoencephalography (MEG) allows investigation of neural circuit function via imaging of brain waves (known as neural oscillations) that index information processing in the brain and would prove a reliable, objective, biomarker. These measures of brain function establish how regions communicate to form brain circuits that support thinking and behaviour. Results: Studies into intrinsic brain function, both during rest and when engaged in a task designed to tap into cognitive dysfunction, have found these neurobiological mechanisms are disrupted in PTSD and are a reliable objective marker of illness. We now know that these alterations in brain function are directly related to core symptoms of PTSD and comorbid cognitive-behavioural challenges. Discussion: Continued characterization of neural function using MEG and related methods will advance understanding of the neurobiology underlying PTSD; allow for the identification of biomarkers that, coupled with machine learning, will aid in diagnoses; provide individualized therapeutic targets for neurostimulation; predict treatment outcomes; and track disorder remission in military personnel and Veterans who are disproportionately affected by this devastating illness.
引用
收藏
页码:16 / 25
页数:10
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