Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation

被引：31
作者：
Tan, Rui P. A. [1 ]
Leshchyns'ka, Iryna [1 ]
Sytnyk, Vladimir [1 ]
机构：
[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2017年 / 10卷
基金：
英国医学研究理事会;
关键词：
cell adhesion molecules; neuronal; GPI anchor; synapses; neurite outgrowth; synaptic plasticity (LTP/LTD); learning and memory; MEMBRANE-PROTEIN LAMP; FIBRONECTIN-TYPE-III; IGLON FAMILY PROTEINS; NEURITE OUTGROWTH; IG SUPERFAMILY; HETEROPHILIC INTERACTIONS; MONOCLONAL-ANTIBODY; EXPRESSION PROFILE; HOMOPHILIC BINDING; FUNCTIONAL LIGAND;
D O I：
10.3389/fnmol.2017.00378
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system. While typical IgSF CAMs are transmembrane molecules, this superfamily also includes CAMs, which do not possess transmembrane and intracellular domains and are instead attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. In this review, we focus on the role GPI-anchored IgSF CAMs have as signal transducers and ligands in neurons, and discuss their functions in regulation of neuronal development, synapse formation, synaptic plasticity, learning, and behavior. We also review the links between GPI-anchored IgSF CAMs and brain disorders.
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页数：16
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