Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents

被引：71

作者：

Hillsley, K ^{[1
]}

Grundy, D ^{[1
]}

机构：

[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

来源：

NEUROSCIENCE LETTERS | 1998年 / 255卷 / 02期

关键词：

serotonin; cholecystokinin; vagus; sensory; jejunum; small intestine; food intake;

D O I：

10.1016/S0304-3940(98)00690-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This electrophysiological study was performed to elucidate the interactions of serotonin (5-hydroxytryptamine, 5-HT) and cholecystokinin (CCK) on mesenteric afferents supplying the rat jejunum. 5-HT and CCK produced characteristic responses in multi-unit recordings of mesenteric afferents. Waveform analysis to extract single units from the whole nerve recording identified populations of single afferents that were sensitive to either 5-HT or CCK, but not both. Furthermore, devazepide (0.5 mg/kg) completely abolished the response to CCK without altering the response to 5-HT while granisetron (0.5 mg/kg) abolished the response to 5-HT with no effect on the response to CCK. These results suggest that there are discrete, noninteractive populations of jejunal afferents that possess either 5-HT3 or CCK-A receptors but not both. (C) 1998 Published by Elsevier Science Ireland Ltd. AIl rights reserved.

引用

页码：63 / 66

页数：4

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