A pneumonia outbreak associated with a new coronavirus of probable bat origin

被引：7607

作者：

Zhou, Peng ^{[1
]}

Yang, Xing-Lou ^{[1
]}

Wang, Xian-Guang ^{[2
]}

Hu, Ben ^{[1
]}

Zhang, Lei ^{[1
]}

Zhang, Wei ^{[1
]}

Si, Hao-Rui ^{[1
,3
]}

Zhu, Yan ^{[1
]}

Li, Bei ^{[1
]}

Huang, Chao-Lin ^{[2
]}

Chen, Hui-Dong ^{[2
]}

Chen, Jing ^{[1
,3
]}

Luo, Yun ^{[1
,3
]}

Guo, Hua ^{[1
,3
]}

Jiang, Ren-Di ^{[1
,3
]}

Liu, Mei-Qin ^{[1
,3
]}

Chen, Ying ^{[1
,3
]}

Shen, Xu-Rui ^{[1
,3
]}

Wang, Xi ^{[1
,3
]}

Zheng, Xiao-Shuang ^{[1
,3
]}

Zhao, Kai ^{[1
,3
]}

Chen, Quan-Jiao ^{[1
]}

Deng, Fei ^{[1
]}

Liu, Lin-Lin ^{[4
]}

Yan, Bing ^{[1
]}

Zhan, Fa-Xian ^{[4
]}

Wang, Yan-Yi ^{[1
]}

Xiao, Geng-Fu ^{[1
]}

Shi, Zheng-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens, Wuhan, Peoples R China

[2] Wuhan Jin Yin Tan Hosp, Wuhan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Hubei Prov Ctr Dis Control & Prevent, Wuhan, Peoples R China

来源：

NATURE | 2020年 / 579卷 / 7798期

关键词：

SARS; IDENTIFICATION;

D O I：

10.1038/s41586-020-2012-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1-4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5-7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

引用

页码：270 / +

页数：16

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