One-Pot Synthesis of Multiarylated Benzophenones via [3+2+1] Benzannulation of Ketones, Alkynes, and α,β-Unsaturated Carbonyls

被引：7

作者：

Nagahata, Shoko ^{[1
]}

Takei, Seiya ^{[1
]}

Ueno, Satoshi ^{[1
]}

机构：

[1] Tokyo Univ Technol, Grad Sch Engn, Dept Appl Chem, Hachioji, Tokyo 1920982, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 15期

关键词：

FRIEDEL-CRAFTS ACYLATION; REGIOSELECTIVE SYNTHESIS; ALDEHYDES; ANTHRAQUINONE; ARYLATION; CATALYST;

D O I：

10.1021/acs.joc.2c00601

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we synthesized gamma-phenyl-beta,gamma-unsaturated ketones in situ from acetophenones and phenylacetylenes under Trofimov's conditions using KOtBu in a dimethyl sulfoxide (DMSO) solvent. The obtained ketones reacted with alpha,beta-unsaturated carbonyls in a one-pot manner, forming tri- or diarylated benzophenones. The present reaction proceeded efficiently by one-pot manipulation with a suitable carboxylic acid.

引用

页码：10377 / 10384

页数：8

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