CT-Defined Prosthesis-Patient Mismatch Downgrades Frequency and Severity, and Demonstrates No Association With Adverse Outcomes After Transcatheter Aortic Valve Replacement

被引：46

作者：

Mooney, John ^{[1
]}

Sellers, Stephanie L. ^{[1
]}

Blanke, Phillip ^{[1
]}

Pibarot, Philippe ^{[2
]}

Hahn, Rebecca T. ^{[3
]}

Dvir, Danny ^{[4
]}

Douglas, Pamela S. ^{[5
]}

Weissman, Neil J. ^{[6
]}

Kodali, Susheel K. ^{[3
]}

Thourani, Vinod H. ^{[7
]}

Jilaihawi, Hasan ^{[8
]}

Khalique, Omar ^{[3
]}

Smith, Craig R. ^{[3
]}

Kueh, Shaw Hua ^{[1
]}

Ohana, Mickael ^{[1
]}

Grover, Romi ^{[1
]}

Naoum, Christopher ^{[1
]}

Crowley, Aaron ^{[9
]}

Jaber, Wael A. ^{[10
]}

Alu, Maria C. ^{[3
]}

Parvataneni, Rupa ^{[9
]}

Mack, Michael ^{[11
]}

Webb, John G. ^{[1
]}

Leon, Martin B. ^{[3
]}

Leipsic, Jonathon A. ^{[1
]}

机构：

[1] St Pauls Hosp, Vancouver, BC, Canada

[2] Univ Laval, Quebec City, PQ, Canada

[3] Columbia Univ, Med Ctr, New York, NY USA

[4] Univ Washington, Seattle, WA 98195 USA

[5] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

[6] Georgetown Univ, Sch Med, Medstar Hlth Res Inst, Washington, DC USA

[7] Emory Univ, Sch Med, Atlanta, GA USA

[8] NYU Langone Med Ctr, New York, NY USA

[9] Cardiovasc Res Fdn, New York, NY USA

[10] Cleveland Clin, Cleveland, OH 44106 USA

[11] Baylor Scott & White Hlth, Plano, TX USA

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2017年 / 10卷 / 15期

关键词：

VENTRICULAR OUTFLOW TRACT; LONG-TERM SURVIVAL; ECHOCARDIOGRAPHIC-ASSESSMENT; RISK PATIENTS; STENOSIS; IMPACT; AREA; RECOMMENDATIONS; DOPPLER; SURGERY;

D O I：

10.1016/j.jcin.2017.05.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES This study sought to determine if indexed effective orifice area (EOAi), using left ventricular outflow tract measured from computed tomography (EOAi(CT)), reclassified prosthesis-patient mismatch (PPM) compared with conventional echocardiogram-defined measurements (EOAi(TTE)). BACKGROUND PPM does not predict mortality following transcatheter aortic valve replacement (TAVR). However, it is unknown if the EOAi(CT) of the left ventricular outflow tract improves risk stratification. METHODS A total of 765 TAVR patients from the PARTNER II (Placement of Aortic Transcatheter Valves II) trial S3i cohort were evaluated. EOAi was calculated using the continuity equation, and the left ventricular outflow tract area was derived from baseline computed tomography. Traditional echocardiographic categories defined PPM: absent (> 0.85 cm(2)/m(2)), moderate (>= 0.65 and <= 0.85 cm(2)/m(2)), or severe (<= 0.65 cm(2)/m(2)). Correlation of EOAi(CT) and EOAi(TTE) to 1-year outcomes was performed. RESULTS The incidence of PPM was 24% with EOA(CT) compared with 45% with EOAi(TTE). Only 6% of PPM was graded severe by EOAi(CT) compared with 9% by EOAi(TTE). EOAi(TTE), but not EOAi(CT), defined PPM showed association with reduced left ventricular mass regression (p = 0.03 vs. p = 0.52). There was no association between PPM and death or rehospitalization at 1 year with either modality. EOA(CT) was associated with minor stroke at 1 year (log-rank p = 0.04), and EOAi(TTE) with stroke/transient ischemic attack (log-rank p = 0.030). Furthermore, when subjects with mild or greater paravalvular regurgitation were excluded, the presence of PPM did not show association with any outcome. CONCLUSIONS EOAi(CT) downgrades frequency and severity of PPM in patients after TAVR, and was not associated with mortality 1 year after TAVR. EOAi(TTE), but not EOAi(CT), was associated with less left ventricular mass regression. (C) 2017 by the American College of Cardiology Foundation.

引用

页码：1578 / 1587

页数：10

共 24 条

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