Cu-Catalyzed Aqueous Phase Ullmann-Type C-N Coupling Reaction Promoted by Glycosyl Ligand

被引：6

作者：

Liu, Xuemin ^{[1
]}

Chen, Wen ^{[1
]}

Ni, Bangqing ^{[1
]}

Chen, Xinzhi ^{[2
]}

Qian, Chao ^{[2
]}

Ge, Xin ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

[2] Zhejiang Univ, Zhejiang Prov Key Lab Adv Chem Engn Manufacture T, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 07期

基金：

中国国家自然科学基金;

关键词：

copper; Ullmann reaction; glycosyl ligand; water; AMINO-ACIDS; ARYL HALIDES; ARYLATION; EFFICIENT; WATER; COPPER(I); PROGRESS; COMPLEX; ORGANOCATALYSTS; PALLADIUM(II);

D O I：

10.6023/cjoc201801031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and efficient catalytic system has been developed for the Cu-catalyzed Ullmann-type C-N coupling reactions in water. With CuI as catalyst, N-(2-hydroxyethyl)-beta-D-glucopyranosylamine as ligand, aryl iodides and aryl bromides bearing various electron-withdrawing and electron-donating groups could be coupled with N-nucleophiles in water with good yields (61%similar to 96%). The catalytic system was expanded successfully to the reaction of indoles with 4-iodoanisole in water.

引用

页码：1703 / 1711

页数：9

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