Isolation and Confirmation of the Proposed Cleistanthol Biogentic Link from Croton insularis

被引：33

作者：

Maslovskaya, Lidia A. ^{[2
]}

Savchenko, Andrei I. ^{[1
]}

Gordon, Victoria A. ^{[3
]}

Reddell, Paul W. ^{[3
]}

Pierce, Carly J. ^{[2
]}

Parsons, Peter G. ^{[2
]}

Williams, Craig M. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[2] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[3] EcoBiotics Ltd, Yungaburra, Qld 4884, Australia

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

关键词：

ABSOLUTE STEREOCHEMISTRY; ANTICANCER AGENTS; DITERPENES; PIMARANE; CONFIGURATION; CONVERSION; EBC-23; ROOTS; ACID;

D O I：

10.1021/ol103083m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The proposed cleistanthol biosynthetic intermediate en route to spruceanol, and other related family members, was isolated for the first time from Croton insularis, confirming the Jacobs-Reynolds hypothesis. Anticancer evaluation of the new isolates and their aerial oxidation products is also reported.

引用

页码：1032 / 1035

页数：4

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