Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways

被引：25
作者：
Malon, Jennifer T. [1 ]
Cao, Ling [1 ]
机构：
[1] Univ New England, Dept Biomed Sci, Coll Osteopath Med, 11 Hills Beach Rd, Biddeford, ME 04005 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 297卷
关键词：
Calcitonin gene-related peptide (CGRP); CCL5; Neuropathic pain; Spinal nerve L5 transection; p38; Spinal cord; SPINAL-CORD ASTROCYTES; NEUROPATHIC PAIN MODEL; CYTOMETRIC BEAD ARRAY; SUBSTANCE-P; RAT; CHEMOKINE; ALLODYNIA; RESPONSES; MAPK; ACTIVATION;
D O I：
10.1016/j.jneuroim.2016.05.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of calcitonin gene related peptide (CGRP) in neuropathic pain was investigated in a mouse model of neuropathic pain, spinal nerve L5 transection (L5Tx). Intrathecal injection (i.t.) of CGRP(8-37), a CGRP antagonist, significantly reduced L5Tx-induced mechanical hypersensitivity and lumbar spinal cord CCL5 expression. i.t. injection of a CCL5 neutralizing antibody significantly inhibited L5Tx-induced mechanical hypersensitivity. Further, pre-treatment with a p38-inhibitor, SB203580, was able to reduce CGRP-induced mechanical hypersensitivity, but not CGRP-induced CCL5 production. Our data indicate that CGRP can play its pro-nociceptive role through both a spinal cord CCL5-dependent, p38-independent pathway, and a p38-depenented, CCL5-independent pathway. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：68 / 75
页数：8
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