IMS-MS studies based on coupling a differential mobility analyzer (DMA) to commercial API-MS systems

被引：100

作者：

Rus, Juan ^{[2
]}

Moro, David ^{[2
]}

Antonio Sillero, Juan ^{[1
,2
]}

Royuela, Javier ^{[2
]}

Casado, Alejandro ^{[2
]}

Estevez-Molinero, Francisco ^{[1
,2
]}

Fernandez de la Mora, Juan ^{[1
]}

机构：

[1] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA

[2] SEADM, Valladolid, Spain

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2010年 / 298卷 / 1-3期

关键词：

Differential mobility analyzer; DMA; Cluster; Air; Tetrahexylammonium; Metastable; Charge loss; Electrospray; CLUSTERS; IONS;

D O I：

10.1016/j.ijms.2010.05.008

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Recent progress in adding a mobility dimension to preexisting API-MS systems without modifying the MS itself is discussed, based on inserting a differential mobility analyzer (DMA) as part of the MS's atmospheric pressure ion source. Design criteria leading to high DMA resolving power R and transmission efficiency eta are discussed. Various DMA prototypes have been interfaced to several triple quadrupoles, a single quadrupole and a quadrupole-TOF, all demonstrating R>50 and eta > 50%. We obtain two-dimensional DMA-MS spectra of the multiply charged clusters formed in electrosprays of concentrated solutions of tetrahexylammonium bromide (A(+)Br(-)). These reveal systematic loss of (ABr)A(+) fragments from unstable multiply charged clusters, and provide mobility measurements in air on mass resolved (ABr)(n)(A(+))(z) clusters with n > 100 and z up to 10. Well-defined bands of ions not individually resolved are clearly visible at considerably larger n and z values. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：30 / 40

页数：11

共 28 条

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