Terahertz pulsed imaging of cancers

被引:10
作者
Wallace, VP [1 ]
Woodward, RM [1 ]
Fitzgerald, AJ [1 ]
Pickwell, E [1 ]
Pye, RJ [1 ]
Arnone, DA [1 ]
机构
[1] TeraView Ltd, Cambridge, England
来源
LASERS IN SURGERY: ADVANCED CHARACTERIZATION, THERAPEUTICS, AND SYSTEMS XIII | 2003年 / 4949卷
关键词
Terahertz; skin; cancer; imaging;
D O I
10.1117/12.500121
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Over the last decade advances in laser and semiconductor technology has allowed the investigation of terahertz region of the electromagnetic spectrum as a potential tool for medical imaging. The terahertz frequency range covers the far infrared wavelenaths and is sensitive to librational and vibrational modes of molecules. Terahertz radiation is non-ionizing and is not highly scattered like visible and near infrared fight. Terahertz Pulsed Imaging (TPI) has already been demonstrated as an effective tool for differentiating between tissue types in particular normal skin and basal cell carcinoma in vitro. TPI may prove advantageous in distinguishing type, lateral spread and depth of tumours. Here we present recent ex vivo results obtained with a portable TPI system in a clinical setting. It is hoped that this technique could be applied to other epithelial tissues, which give rise to more than 80% of all adult cancers and include common cancers of the skin, oral cavity, breast, colon and prostate.
引用
收藏
页码:353 / 359
页数:7
相关论文
共 16 条
[1]  
*AM CANC SOC, 2001, CANC FACTS FIG
[2]   Applications of Terahertz (THz) technology to medical imaging [J].
Arnone, DD ;
Ciesla, CM ;
Corchia, A ;
Egusa, S ;
Pepper, M ;
Chamberlain, JM ;
Bezant, C ;
Linfield, EH ;
Clothier, R ;
Khammo, N .
TERAHERTZ SPECTROSCOPY AND APPLICATIONS 11, 1999, 3828 :209-219
[3]  
BERRY E, IN PRESS J LASER APP
[4]  
CLOTHIER R, UNPUB COMMUNICATION
[5]  
COLE BE, 2000, P SOC PHOTO-OPT INS, V4276, P11
[6]   Time-domain transillumination of biological tissues with terahertz pulses [J].
Han, PY ;
Cho, GC ;
Zhang, XC .
OPTICS LETTERS, 2000, 25 (04) :242-244
[7]   Quantitative assessment of protein content in irradiated human skin [J].
Lahtinen, T ;
Nuutinen, J ;
Alanen, E ;
Turunen, M ;
Nuortio, L ;
Usenius, T ;
Hopewell, JW .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 43 (03) :635-638
[8]  
PYE R, 2000, ROYAL COLL PHYSICIAN, V12, P339
[9]   Mohs micrographic surgery [J].
Shriner, DL ;
McCoy, DK ;
Goldberg, DJ ;
Wagner, RF .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 39 (01) :79-97
[10]  
Telfer NR, 1999, BRIT J DERMATOL, V141, P415