Psychiatric Disorders in Adult and Paediatric Patients With Inflammatory Bowel Diseases - A Systematic Review and Meta-Analysis

被引:20
作者
Arp, Laura [1 ,2 ]
Jansson, Sabine [2 ,3 ]
Wewer, Vibeke [2 ,3 ]
Burisch, Johan [1 ,2 ]
机构
[1] Copenhagen Univ Hosp Amager & Hvidovre, Gastrounit, Med Sect, Hvidovre, Denmark
[2] Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ad, Hvidovre, Denmark
[3] Copenhagen Univ Hosp Amager & Hvidovre, Paediat Dept, Hvidovre, Denmark
关键词
Inflammatory bowel disease; Crohn's disease; ulcerative colitis; mental disorders; QUALITY-OF-LIFE; ULCERATIVE-COLITIS; RISK-FACTORS; MEDICATION NONADHERENCE; AUTOIMMUNE-DISEASES; BIPOLAR DISORDER; CROHNS-DISEASE; NARCOTIC USE; DEPRESSION; ANXIETY;
D O I
10.1093/ecco-jcc/jjac095
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Inflammatory bowel diseases [IBD], which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed. Methods This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO [ID: CRD42020214359]. PubMed, Embase and PsycINFO were consulted for the literature search. Studies reporting on diagnosed psychiatric disorders in IBD were included. Pooled prevalence rates were calculated using random effects meta-analyses. Study quality was assessed using the Newcastle-Ottawa Scale [NOS]. Results Sixty-nine studies were identified with an average cohort size of 60 114 patients. Pooled prevalence rates were: mood disorders, 10% (95% confidence interval [CI] = 7%; 15%); anxiety disorders, 12% [95% CI = 8%; 18%]; substance misuse, 3% [95% CI = 1%; 7%]; psychotic disorders, 2% [95% CI = 1%; 4%]; behavioural disorders, 1% [95% CI = 0%; 3%]; personality disorders, 3% [95% CI = 1%; 10%]; developmental disorders, 1% [95% CI = 0%; 3%]; and behavioural and emotional disorders with onset usually during childhood, 1% [95% CI = 1%; 3%]. All analyses had high statistical heterogeneity [I-2 > 99%]. Seven studies reported an increased risk of suicide in IBD patients compared to controls. Conclusion The prevalence of psychiatric comorbidities was high [11-82%] in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality.
引用
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页码:1933 / 1945
页数:13
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