Etiological and epidemiological features of acute respiratory infections in China

被引：409

作者：

Li, Zhong-Jie ^{[1
]}

Zhang, Hai-Yang ^{[2
]}

Ren, Li-Li ^{[3
,4
]}

Lu, Qing-Bin ^{[5
]}

Ren, Xiang ^{[1
]}

Zhang, Cui-Hong ^{[1
]}

Wang, Yi-Fei ^{[1
]}

Lin, Sheng-Hong ^{[1
]}

Zhang, Xiao-Ai ^{[2
]}

Li, Jun ^{[6
]}

Zhao, Shi-Wen ^{[7
]}

Yi, Zhi-Gang ^{[8
]}

Chen, Xiao ^{[9
]}

Yang, Zuo-Sen ^{[10
]}

Meng, Lei ^{[11
]}

Wang, Xin-Hua ^{[11
]}

Liu, Ying-Le ^{[12
]}

Wang, Xin ^{[13
]}

Cui, Ai-Li ^{[14
]}

Lai, Sheng-Jie ^{[1
,15
,16
]}

Jiang, Tao ^{[2
]}

Yuan, Yang ^{[2
]}

Shi, Lu-Sha ^{[1
]}

Liu, Meng-Yang ^{[2
]}

Zhu, Yu-Liang ^{[1
]}

Zhang, An-Ran ^{[2
]}

Zhang, Zhi-Jie ^{[17
]}

Yang, Yang ^{[18
,19
]}

Ward, Michael P. ^{[20
]}

Feng, Lu-Zhao ^{[1
]}

Jing, Huai-Qi ^{[13
]}

Huang, Liu-Yu ^{[21
]}

Xu, Wen-Bo ^{[14
]}

Chen, Yu ^{[9
]}

Wu, Jian-Guo ^{[12
]}

Yuan, Zheng-Hong ^{[22
]}

Li, Meng-Feng ^{[6
]}

Wang, Yu ^{[23
]}

Wang, Li-Ping ^{[1
]}

Fang, Li-Qun ^{[2
]}

Liu, Wei ^{[2
]}

Hay, Simon, I ^{[24
,25
]}

Gao, George F. ^{[23
]}

Yang, Wei-Zhong ^{[23
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Div Infect Dis, Key Lab Surveillance & Early Warning Infect Dis, Beijing, Peoples R China

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Pathogen Biol, Beijing, Peoples R China

[4] Peking Union Med Coll, Beijing, Peoples R China

[5] Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing, Peoples R China

[6] Sun Yat Sen Univ, Guangzhou, Peoples R China

[7] Yunnan Ctr Dis Control & Prevent, Kunming, Yunnan, Peoples R China

[8] Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China

[9] Zhejiang Univ, Hangzhou, Peoples R China

[10] Liaoning Prov Ctr Dis Control & Prevent, Shenyang, Peoples R China

[11] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Peoples R China

[12] Wuhan Univ, Wuhan, Peoples R China

[13] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Beijing, Peoples R China

[14] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

[15] Univ Southampton, Sch Geog & Environm Sci, Southampton, Hants, England

[16] Fudan Univ, Key Lab Publ Hlth Safety, Minist Educ, Sch Publ Hlth, Shanghai, Peoples R China

[17] Fudan Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Shanghai, Peoples R China

[18] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Biostat, Gainesville, FL USA

[19] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA

[20] Univ Sydney, Sydney Sch Vet Sci, Camden, NSW, Australia

[21] Inst Dis Prevent & Control PLA, Beijing, Peoples R China

[22] Fudan Univ, Shanghai, Peoples R China

[23] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[24] Univ Washington, Sch Med, Dept Hlth Metr Sci, Seattle, WA USA

[25] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; STREPTOCOCCUS-PNEUMONIAE; REQUIRING HOSPITALIZATION; RHINOVIRUS INFECTION; SYNCYTIAL VIRUS; INFLUENZA; BACTERIAL; CHILDREN; ADULTS;

D O I：

10.1038/s41467-021-25120-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009.2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and schoolage children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.

引用

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