Receiver-operating characteristics of adiposity for metabolic syndrome: the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study

被引:31
作者
Beydoun, May A. [1 ]
Kuczmarski, Marie T. Fanelli [2 ]
Wang, Youfa [3 ]
Mason, Marc A. [4 ]
Evans, Michele K. [1 ]
Zonderman, Alan B. [1 ]
机构
[1] NIA, NIA NIH IRP, NIH Biomed Res Ctr, Baltimore, MD 21224 USA
[2] Univ Delaware, Dept Hlth Nutr & Exercise Sci, Newark, DE USA
[3] Johns Hopkins Univ, Dept Int Hlth, Ctr Human Nutr, Baltimore, MD USA
[4] MedStar Res Inst, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
Metabolic syndrome; Percentage total body fat mass; Central obesity; BMI; BODY-MASS INDEX; ALL-CAUSE MORTALITY; DIFFERENT ANTHROPOMETRIC MEASUREMENTS; BIOELECTRICAL-IMPEDANCE ANALYSIS; X-RAY ABSORPTIOMETRY; TO-HIP RATIO; WAIST CIRCUMFERENCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; CHARACTERISTIC CURVES;
D O I
10.1017/S1368980010002648
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: To assess the predictive values of various adiposity indices for metabolic syndrome (MetS) among adults using baseline data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) cohort. Design: In a cross-sectional study, BMI, waist circumference (WC), body composition by dual-energy X-ray absorptiometry (DEXA) and metabolic risk factors such as TAG, HDL cholesterol, blood pressure, fasting glucose and insulin, uric acid and C-reactive protein were measured. Receiver-operating characteristic (ROC) curves and logistic regression analyses were conducted. Setting: Baltimore, Maryland. Subjects: White and African-American US adults (n 1981), aged 30-64 years. Results: In predicting risk of MetS using obesity-independent National Cholesterol Education Program Adult Treatment Panel III criteria, percentage total body fat mass (TtFM) assessed using DEXA measuring overall adiposity had no added value over WC. This was true among both men (area under the ROC curve (AUC) = 0.680 v. 0.733 for TtFM and WC, respectively; P < 0.05) and women (AUC = 0.581 v. 0.686). Percentage rib fat mass (RbFM) was superior to TtFM only in women for MetS (AUC = 0.701 and 0.581 for RbFM and TtFM, respectively; P < 0.05), particularly among African-American women. Elevated percentage leg fat mass (LgFM) was protective against MetS among African-American men. Among white men, BMI was inferior to WC in predicting MetS. Optimal WC cut-off points varied across ethnic-sex groups and differed from those recommended by the National Institutes of Health/North American Association for the Study of Obesity. Conclusions: The study provides evidence that WC is among the most powerful tools to predict MetS, and that optimal cut-off points for various indices including WC may differ by sex and race.
引用
收藏
页码:77 / 92
页数:16
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