The role of HOX genes in human implantation

被引：75

作者：

Kwon, HE ^{[1
]}

Taylor, HS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Div Reprod Endocrinol, Dept Obstet & Gynecol, New Haven, CT 06520 USA

来源：

UTERUS AND HUMAN REPRODUCTION | 2004年 / 1034卷

关键词：

HOX; implantation; sex steroids; uterus; development;

D O I：

10.1196/annals.1335.001

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endometrium undergoes an ordered process of differentiation leading to receptivity to embryonic implantation. HOX genes direct this development in a fashion similar to that in which they direct embryonic development, including development of the reproductive tract. HOXA10 and HOXA11 expression increases during the menstrual cycle, increasing drastically in the midluteal phase, at the time of implantation. This expression is regulated by sex steroid hormones. This expression is necessary for implantation of the blastocyst as demonstrated by the decreased implantation rates in women with altered HOX expression. HOX genes are markers of endometrial receptivity. The possibility of augmenting HOX gene expression with gene therapy to improve implantation has promise for the future.

引用

页码：1 / 18

页数：18

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