Correlation of proband and sibling stroke latency: The SWISS Study

被引：4

作者：

Meschia, JF

Brott, TG

Brown, RD

Kissela, BM

Hardy, JA

Brown, WM

Rich, SS

机构：

[1] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[2] Mayo Clin, Dept Neurol, Rochester, MN USA

[3] Univ Cincinnati, Dept Neurol, Cincinnati, OH USA

[4] NIA, Bethesda, MD 20892 USA

[5] Wake Forest Univ, Dept Biostat, Sch Med, Winston Salem, NC 27109 USA

来源：

NEUROLOGY | 2005年 / 64卷 / 06期

关键词：

D O I：

10.1212/01.WNL.0000154602.20719.E8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors found a correlation between the age at which probands experience an incident stroke and the age at which their siblings experience an incident stroke (r = 0.68; p < 0.0001). Proband-sibling incident stroke latency correlations were observed in analyses restricted to siblings concordant for smoking (r = 0.68; p < 0.0001), diabetes (r = 0.73; p < 0.0001), and hypertension (r = 0.63; p < 0.0001). In the authors' cohort of affected sibling pairs, inherited factors were important determinants of incident ischemic stroke latency.

引用

页码：1061 / 1063

页数：3

共 7 条

[1] CLASSIFICATION OF SUBTYPE OF ACUTE ISCHEMIC STROKE - DEFINITIONS FOR USE IN A MULTICENTER CLINICAL-TRIAL [J].

ADAMS, HP ;

BENDIXEN, BH ;

KAPPELLE, LJ ;

BILLER, J ;

LOVE, BB ;

GORDON, DL ;

MARSH, EE ;

KASE, CS ;

WOLF, PA ;

BABIKIAN, VL ;

LICATAGEHR, EE ;

ALLEN, N ;

BRASS, LM ;

FAYAD, PB ;

PAVALKIS, FJ ;

WEINBERGER, JM ;

TUHRIM, S ;

RUDOLPH, SH ;

HOROWITZ, DR ;

BITTON, A ;

MOHR, JP ;

SACCO, RL ;

CLAVIJO, M ;

ROSENBAUM, DM ;

SPARR, SA ;

KATZ, P ;

KLONOWSKI, E ;

CULEBRAS, A ;

CAREY, G ;

MARTIR, NI ;

FICARRA, C ;

HOGAN, EL ;

CARTER, T ;

GURECKI, P ;

MUNTZ, BK ;

RAMIREZLASSEPAS, M ;

TULLOCH, JW ;

QUINONES, MR ;

MENDEZ, M ;

ZHANG, SM ;

ALA, T ;

JOHNSTON, KC ;

ANDERSON, DC ;

TARREL, RM ;

NANCE, MA ;

BUDLIE, SR ;

DIERICH, M ;

HELGASON, CM ;

HIER, DB ;

SHAPIRO, RA .

STROKE, 1993, 24 (01) :35-41

[2] Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke [J].

Flossmann, E ;

Schulz, UGR ;

Rothwell, PM .

STROKE, 2004, 35 (01) :212-227

[3]

GOOD P, 1994, PERMUTATION TESTS PR

[4]

Meschia James F, 2002, BMC Med Genet, V3, P1, DOI 10.1186/1471-2350-3-1

[5] Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease [J].

Rubattu, S ;

Volpe, M ;

Kreutz, R ;

Ganten, U ;

Ganten, D ;

Lindpaintner, K .

NATURE GENETICS, 1996, 13 (04) :429-434

[6] Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies [J].

Schulz, UGR ;

Flossmann, E ;

Rothwell, PM .

STROKE, 2004, 35 (04) :819-824

[7] Stable stroke occurrence despite incidence reduction in an aging population - Stroke trends in the Danish Monitoring Trends and Determinants in Cardiovascular Disease (MONICA) population [J].

Thorvaldsen, P ;

Davidsen, M ;

Bronnum-Hansen, H ;

Schroll, M .

STROKE, 1999, 30 (12) :2529-2534

← 1 →