Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference

被引：12

作者：

Mclin, Valerie A. ^{[1
]}

Allen, Upton ^{[2
]}

Boyer, Olivia ^{[3
]}

Bucuvalas, John ^{[4
]}

Colledan, Michele ^{[5
]}

Cuturi, Maria-Cristina ^{[6
]}

d'Antiga, Lorenzo ^{[7
]}

Debray, Dominique ^{[8
]}

Dezsofi, Antal ^{[9
]}

de Goyet, Jean de Ville ^{[10
]}

Dhawan, Anil ^{[11
]}

Durmaz, Ozlem ^{[12
]}

Falk, Christine ^{[13
]}

Feng, Sandy ^{[14
]}

Fischler, Bjorn ^{[15
]}

Franchi-Abella, Stephanie ^{[16
]}

Frauca, Esteban ^{[17
]}

Ganschow, Rainer ^{[18
]}

Gottschalk, Stephen ^{[19
,20
]}

Hadzic, Nedim ^{[21
]}

Hierro, Loreto ^{[17
]}

Horslen, Simon ^{[22
,23
]}

Hubscher, Stefan ^{[24
,25
]}

Karam, Vincent ^{[26
]}

Kelly, Deirdre ^{[27
]}

Maecker-Kolhoff, Britta ^{[28
,29
]}

Mazariegos, George ^{[30
]}

McKiernan, Patrick ^{[27
]}

Melk, Anette ^{[31
]}

Nobili, Valerio ^{[32
]}

Ozgenc, Funda ^{[33
]}

Reding, Raymond ^{[34
]}

Sciveres, Marco ^{[35
]}

Sharif, Khalid ^{[27
]}

Socha, Piotr ^{[36
]}

Toso, Christian ^{[37
,38
]}

Vajro, Pietro ^{[39
]}

Verma, Anita ^{[40
]}

Wildhaber, Barbara E. ^{[1
]}

Baumann, Ulrich ^{[41
]}

机构：

[1] Univ Hosp Geneva, Swiss Ctr Liver Dis Children, Rue Willy Donze 6, CH-1205 Geneva, Switzerland

[2] Univ Toronto, Hosp Sick Children, Div Infect Dis & Transplant & Regenerat Med Ctr, Toronto, ON, Canada

[3] Paris Descartes Univ Sorbonne Paris Cite, Necker Enfants Malades Hosp, AP HP, Imagine Inst,Pediat Nephrol, Paris, France

[4] Cincinnati Childrens Hosp, Pediat Liver Care Ctr, Cincinnati, OH USA

[5] Osped Papa Giovanni XXIII, Dept Surg, Bergamo, Italy

[6] Univ Nantes, Fac Med, Nantes, France

[7] Osped Papa Giovanni XXIII, Pediat Hepatol Gastroenterol & Trans plantat, Bergamo, Italy

[8] Necker Enfants Malades Hosp, Pediat Hepatol Unit, Paris, France

[9] Semmelweis Univ, Dept Pediat 1, Budapest, Hungary

[10] Univ Tor Vergata, Rome, Italy

[11] Kings Coll Hosp London, Pediat Liver GI & Nutr Ctr, London, England

[12] Istanbul Univ, Fac Med, Istanbul, Turkey

[13] Hannover Med Sch, Inst Transplant Immunol, FIB Tx, Hannover, Germany

[14] Univ Calif San Francisco, Abdominal Transplant Surg, San Francisco, CA 94143 USA

[15] Karolinska Univ Hosp, Dept Pediat, CLINTEC Karolinska Inst, Stockholm, Sweden

[16] Hop Univ Paris Sud, AP HP, Hop Bicetre, Dept Pediat Radiol, Le Kremlin Bicetre, France

[17] Hosp Univ Infantil Paz, Pediat Hepatol & Liver Transplantat, Madrid, Spain

[18] Univ Childrens Hosp Bonn, Dept Pediat, Bonn, Germany

[19] Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[20] Texas Childrens Hosp, Coll Med, Houston Methodist Hosp, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[21] Kings Coll London, Pediat Liver GI & Nutr Ctr, London, England

[22] Seattle Chil drens Hosp, Seattle, WA USA

[23] Univ Washington, Seattle, WA 98195 USA

[24] Sch Canc Sci, Birmingham, AL USA

[25] Univ Birmingham, Queen Elizabeth Hosp, Dept Cell Pathol, Birmingham, AL USA

[26] Hop Paul Brousse, AP HP, European Transplant Registry, Villejuif, France

[27] Birmingham Childrens Hosp, Liver Unit, Birmingham, W Midlands, England

[28] Hannover Med Sch, Dept Hematol & Oncol, Hannover, Germany

[29] Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat, Hannover, Germany

[30] Childrens Hosp Pittsburgh, Hillman Ctr Pediat Transplantat, Pittsburgh, PA 15213 USA

[31] Univ Salerno, Sect Pediat, Surg & Dent Scuola Med Salernitana, Dept Med, Baronissi, Italy

[32] Bambino Gesu Pediat Hosp, Rome, Italy

[33] Ege Univ, Dept Pediat Gastroenterol Hepatol & Nutr, Izmir, Turkey

[34] Catholic Univ Louvain, Clin Univ St Luc, Pediatr Surg & Transplantat Unit, Brussels, Belgium

[35] Univ Pittsburgh, Med Ctr, ISMETT, Palermo, Italy

[36] Childrens Mem Hosp, Warsaw, Poland

[37] Fac Med, Div Abdominal & Transplant Surg, Geneva, Switzerland

[38] Univ Hosp Geneva, Geneva, Switzerland

[39] Univ Salerno, Baronissi, Italy

[40] Kings Coll Hosp London, Inst Liver Studies, London, England

[41] Hannover Med Sch, Div Pediat Gastroenterol & Hepatol, Dept Pediat Kidney Liver & Metab Dis, Hannover, Germany

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2017年 / 65卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

complications; liver transplantation; pediatric; research goals; tolerance; MULTICENTER CLINICAL-TRIAL; CYTOTOXIC T-LYMPHOCYTES; QUALITY-OF-LIFE; LYMPHOPROLIFERATIVE DISEASE; BILIARY COMPLICATIONS; ALLOGRAFT RECIPIENTS; CHILDREN; IMMUNOSUPPRESSION; TOLERANCE; FIBROSIS;

D O I：

10.1097/MPG.0000000000001564

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

As pediatric liver transplantation comes of age, experts gathered to discuss current paradigms and define gaps in knowledge warranting research to further improve patient and graft outcomes. Identified areas ripe for collaborative research include understanding the molecular and cellular mechanisms of tolerance and the role of donor-specific antibodies, considering ways to expand donor pool, minimizing long-term side effects of immunosuppression, and fine-tuning surgical techniques to minimize biliary and vascular complications.

引用

页码：E53 / E59

页数：7

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