Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial)

被引：5

作者：

Chang, Chun Chin ^{[1
,2
]}

Spitzer, Ernest ^{[1
,3
]}

Chichareon, Ply ^{[4
]}

Takahashi, Kuniaki ^{[4
]}

Modolo, Rodrigo ^{[4
]}

Kogame, Norihiro ^{[4
]}

Tomaniak, Mariusz ^{[1
,5
]}

Komiyama, Hidenori ^{[4
]}

Yap, Sing-Chien ^{[1
]}

Hoole, Stephen P. ^{[6
]}

Gori, Tommaso ^{[7
,8
]}

Zaman, Azfar ^{[9
]}

Frey, Bernhard ^{[10
]}

Ferreira, Rui Cruz ^{[11
]}

Bertrand, Olivier F. ^{[12
]}

Koh, Tian Hai ^{[13
]}

Sousa, Amanda ^{[14
]}

Moschovitis, Aris ^{[15
]}

van Geuns, Robert-Jan ^{[1
,16
]}

Steg, Philippe Gabriel ^{[17
]}

Hamm, Christian ^{[18
,19
]}

Juni, Peter ^{[20
,21
]}

Vranckx, Pascal ^{[22
]}

Valgimigli, Marco ^{[15
]}

Windecker, Stephan ^{[15
]}

Serruys, Patrick W. ^{[23
]}

Soliman, Osama ^{[1
,3
]}

Onuma, Yoshinobu ^{[1
,3
]}

机构：

[1] Erasmus MC, Thoraxctr, Dept Cardiol, Rotterdam, Netherlands

[2] Natl Yang Ming Univ, Inst Clin Med, Taipei Vet Gen Hosp, Div Cardiol,Dept Internal Med, Taipei, Taiwan

[3] Cardialysis BV, Rotterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

[5] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland

[6] Royal Papworth Hosp, Dept Intervent Cardiol, Cambridge, England

[7] Univ Med Ctr, Kardiol 1, Zentrum Kardiol, Mainz, Germany

[8] DZHK Standort Rhein Main, Mainz, Germany

[9] Newcastle Univ, Newcastle Tyne NHS Hosp Trust & Inst Cellular Med, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[10] Med Univ Vienna, Dept Internal Med 2, Vienna, Austria

[11] Santa Marta Hosp, Dept Cardiol, Lisbon, Portugal

[12] Laval Univ, Quebec Heart Lung Inst, Quebec City, PQ, Canada

[13] Natl Heart Ctr Singapore, Singapore, Singapore

[14] Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil

[15] Univ Bern, Inselspital, Dept Cardiol, Bern, Switzerland

[16] Radboud UMC, Dept Cardiol, Nijmegen, Netherlands

[17] Hop Univ Paris Nord Val Seine, Hop Bichat, AP HP, Dept Cardiol, Paris, France

[18] Kerckhoff Clin, Bad Nauheim, Germany

[19] DZHK German Ctr Cardiovasc Res, Frankfurt, Germany

[20] St Michaels Hosp, Li Ka Shing Knowledge Inst, Appl Hlth Res Ctr, Toronto, ON, Canada

[21] Univ Toronto, Inst Hlth Policy Management & Evaluat, Dept Med, Toronto, ON, Canada

[22] Hasselt Univ, Fac Med & Life Sci, Jessa Ziekenhuis, Hasselt, Belgium

[23] Imperial Coll London, NHLI, London, England

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2019年 / 124卷 / 12期

关键词：

Q-WAVE; CLASSIFICATION; NOVACODE;

D O I：

10.1016/j.amjcard.2019.08.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Q-wave myocardial infarction (QWMI) comprises 2 entities. First, a clinically evident MI, which can occur spontaneously or be related to a coronary procedure. Second, silent MI which is incidentally detected on serial electrocardiographic (ECG) assessment. The prevalence of silent MI after percutaneous coronary intervention (PCI) in the drug-eluting stent era has not been fully investigated. The GLOBAL LEADERS is an all-corners multicenter trial which randomized 15,991 patients who underwent PCI to 2 antiplatelet treatment strategies. The primary end point was a composite of all-cause death or nonfatal new QWMI at 2-years follow-up. ECGs were collected at discharge, 3-month and 2-year visits, and analyzed by an independent ECG core laboratory following the Minnesota code. All new QWMI were further reviewed by a blinded independent cardiologist to identify a potential clinical correlate by reviewing clinical information. Of 15,968 participants, ECG information was complete in 14,829 (92.9%) at 2 years. A new QWMI was confirmed in 186 (1.16%) patients. Transient new Q-waves were observed in 28.5% (53 of 186) of them during the follow-up. The majority of new QWMI (78 %, 146 of 186) were classified as silent MI due to the absence of a clinical correlate. Silent MI accounted for 22.1% (146 of 660) of all MI events. The prevalence of silent MI did not differ significantly between treatment strategies (experimental vs reference: 0.88% vs 0.98%, p = 0.5027). In conclusion, we document the prevalence of silent MI in an all-corners population undergoing PCI in this large-scale randomized trial. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：1833 / 1840

页数：8

共 23 条

[1]

[Anonymous], 2009, The Minnesota code manual of electrocardiographic findings

[2] A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease [J].

Frye R.L. ;

August P. ;

Brooks M.M. ;

Hardison R.M. ;

Kelsey S.F. ;

MacGregor J.M. ;

Orchard T.J. ;

Chaitman B.R. ;

Genuth S.M. ;

Goldberg S.H. ;

Hlatky M.A. ;

Jones T.L.Z. ;

Molitch M.E. ;

Nesto R.W. ;

Sako E.Y. ;

Sobel B.E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (24) :2503-2515

[3]

Barold S S, 1987, Cardiol Clin, V5, P367

[4] Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study [J].

Burgess, David C. ;

Hunt, David ;

Li, LiPing ;

Zannino, Diana ;

Williamson, Elizabeth ;

Davis, Timothy M. E. ;

Laakso, Markku ;

Kesaniemi, Y. Antero ;

Zhang, Jun ;

Sy, Raymond W. ;

Lehto, Seppo ;

Mann, Stewart ;

Keech, Anthony C. .

EUROPEAN HEART JOURNAL, 2010, 31 (01) :92-99

[5] The Bypass Angioplasty Revascularization Investigation 2 Diabetes Randomized Trial of Different Treatment Strategies in Type 2 Diabetes Mellitus With Stable Ischemic Heart Disease Impact of Treatment Strategy on Cardiac Mortality and Myocardial Infarction [J].

Chaitman, Bernard R. ;

Hardison, Regina M. ;

Adler, Dale ;

Gebhart, Suzanne ;

Grogan, Mary ;

Ocampo, Salvador ;

Sopko, George ;

Ramires, Jose A. ;

Schneider, David ;

Frye, Robert L. .

CIRCULATION, 2009, 120 (25) :2529-U44

[6] Methodology of serial ECG classification using an adaptation of the NOVACODE for Q wave myocardial infarction in the bypass angioplasty revascularization investigation (BARI) [J].

Chaitman, BR ;

Zhou, SH ;

Tamesis, B ;

Rosen, A ;

Terry, AB ;

Zumbehl, KM ;

Stocke, K ;

Takase, B ;

Gussak, I ;

Rautaharju, PM .

JOURNAL OF ELECTROCARDIOLOGY, 1996, 29 (04) :265-277

[7] Pathological Q Waves in Myocardial Infarction in Patients Treated by Primary PCI [J].

Delewi, Ronak ;

IJff, Georges ;

van de Hoef, Tim P. ;

Hirsch, Alexander ;

Robbers, Lourens F. ;

Nijveldt, Robin ;

van der Laan, Anja M. ;

van der Vleuten, Pieter A. ;

Lucas, Cees ;

Tijssen, Jan G. P. ;

van Rossum, Albert C. ;

Zijlstra, Felix ;

Piek, Jan J. .

JACC-CARDIOVASCULAR IMAGING, 2013, 6 (03) :324-331

[8]

Hamm CW, [No title captured]

[9] 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials [J].

Hicks, Karen A. ;

Mahaffey, Kenneth W. ;

Mehran, Roxana ;

Nissen, Steven E. ;

Wiviott, Stephen D. ;

Dunn, Billy ;

Solomon, Scott D. ;

Mar-Ler, John R. ;

Teerlink, John R. ;

Farb, Andrew ;

Morrow, David A. ;

Targum, Shari L. ;

Sila, Cathy A. ;

Hai, Mary T. Thanh ;

Jaff, Michael R. ;

Joffe, Hylton V. ;

Cutlip, Donald E. ;

Desai, Akshay S. ;

Lewis, Eldrin F. ;

Gibson, C. Michael ;

Landray, Martin J. ;

Lincoff, A. Michael ;

White, Christopher J. ;

Brooks, Steven S. ;

Rosenfield, Kenneth ;

Domanski, Michael J. ;

Lansky, Alexandra J. ;

McMurray, John J. V. ;

Tcheng, James E. ;

Steinhubl, Steven R. ;

Burton, Paul ;

Mauri, Laura ;

O'Connor, Christopher M. ;

Pfeffer, Marc A. ;

Hung, H. M. James ;

Stockbridge, Norman L. ;

Chaitman, Bernard R. ;

Temple, Robert J. .

CIRCULATION, 2018, 137 (09) :961-972

[10] INCIDENCE AND PROGNOSIS OF UNRECOGNIZED MYOCARDIAL-INFARCTION - AN UPDATE ON THE FRAMINGHAM-STUDY [J].

KANNEL, WB ;

ABBOTT, RD .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (18) :1144-1147

← 1 2 3 →