Innate Antiviral Immune Responses to Hepatitis B Virus

被引：52

作者：

Ait-Goughoulte, Malika ^{[1
,2
,3
]}

Lucifora, Julie ^{[1
,2
,3
]}

Zoulim, Fabien ^{[1
,2
,3
,4
]}

Durantel, David ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, U871, F-69003 Lyon, France

[2] Univ Lyon, UCBL, F-69008 Lyon, France

[3] IFR62 Lyon Est, F-69008 Lyon, France

[4] Hop Hotel Dieu, HCL, F-69002 Lyon, France

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 07期

关键词：

Hepatitis B virus; innate immunity; cytokines; pathogenesis; TOLL-LIKE RECEPTORS; BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION; DENDRITIC CELLS; IN-VIVO; INTERFERON-ALPHA; TERMINAL PROTEIN; VIRAL-HEPATITIS; MXA PROTEIN; BETA GENE;

D O I：

10.3390/v2071394

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B virus (HBV) is a major cause of acute and chronic hepatitis in humans. As HBV itself is currently viewed as a non-cytopathic virus, the liver pathology associated with hepatitis B is mainly thought to be due to immune responses directed against HBV antigens. The outcome of HBV infection is the result of complex interactions between replicating HBV and the immune system. While the role of the adaptive immune response in the resolution of HBV infection is well understood, the contribution of innate immune mechanisms remains to be clearly defined. The innate immune system represents the first line of defense against viral infection, but its role has been difficult to analyze in humans due to late diagnosis of HBV infection. In this review, we discuss recent advances in the field of innate immunity to HBV infection.

引用

页码：1394 / 1410

页数：17

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