MicroRNAs: Possible role in pathogenesis of Parkinson's disease

被引：38
|
作者：
Filatova, E. V. [1 ]
Alieva, A. Kh. [1 ]
Shadrina, M. I. [1 ]
Slominsky, P. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2012年 / 77卷 / 08期
关键词：
microRNA; Parkinson's disease; miRNA-dependent regulation; ALPHA-SYNUCLEIN EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; GENE; PROTEIN; BRAIN; MUTATIONS; MIRNAS; IDENTIFICATION; MECHANISMS; REPRESSION;
D O I：
10.1134/S0006297912080020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parkinson's disease is one of the most common human neurodegenerative disorders caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of human brain. However, causes and mechanisms of the progression of the disease are not yet fully clarified. To date, investigation of the role of miRNAs in norm and pathology is one of the most intriguing and actively developing areas in molecular biology. MiRNAs regulate expression of a variety of genes and can be implicated in pathogenesis of various diseases. Possible role of miRNAs in pathogenesis of Parkinson's disease is discussed in this review.
引用
收藏
页码：813 / 819
页数：7
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