A proposed model of naturally occurring osteoarthritis in the domestic rabbit

被引：36

作者：

Arzi, Boaz ^{[1
,2
]}

Wisner, Erik R. ^{[2
]}

Huey, Daniel J. ^{[1
]}

Kass, Philip H. ^{[3
]}

Hu, Jerry ^{[1
]}

Athanasiou, Kyriacos A. ^{[1
,4
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[2] Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA

[3] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Orthoped Surg, Davis, CA 95616 USA

来源：

LAB ANIMAL | 2012年 / 41卷 / 01期

基金：

美国国家卫生研究院;

关键词：

FULL-THICKNESS DEFECTS; ARTICULAR-CARTILAGE; OSTEOCHONDRAL DEFECTS; FEMOROTIBIAL JOINTS; ANIMAL-MODELS; KNEE; REPAIR; REGENERATION; PROGRESSION; LESIONS;

D O I：

10.1038/laban0112-20

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Osteoarthritis affects one in eight American adults over the age of 25 y and is a leading cause of chronic disability in the US. Translational research to investigate treatments for this naturally occurring joint disease requires an appropriate animal model. The authors conducted a retrospective study to assess the potential of naturally occurring osteoarthritis in the domestic rabbit as a model of the human disease. Analysis of radiographic images showed that the presence and severity of osteoarthritis were significantly influenced by both age and body weight. The most commonly affected joints were the knee and the hip. The findings reported here suggest that the rabbit is an excellent model of spontaneously arising osteoarthritis that may be useful in translational research pertaining to the human disease.

引用

页码：20 / 25

页数：6

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