Association between Prenatal Exposure to PFAS and Fetal Sex Hormones: Are the Short-Chain PFAS Safer?

被引:82
作者
Nian, Min [1 ,2 ]
Luo, Kai [1 ,2 ]
Luo, Fei [1 ,2 ]
Aimuzi, Ruxianguli [1 ,2 ]
Huo, Xiaona [1 ]
Chen, Qian [1 ]
Tian, Ying [1 ,2 ]
Zhang, Jun [1 ,2 ]
机构
[1] Shanghai Jiao Tong Univ Med, Xinhua Hosp, Minist Educ, Shanghai Key Lab Childrens Environm Hlth, Shanghai 200092, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
CORD BLOOD; STEROID-HORMONES; PERFLUOROALKYL SUBSTANCES; PREGNANCY; ENDOCRINE; FOOD;
D O I
10.1021/acs.est.0c02444
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Epidemiologic evidence regarding the effects of in utero exposure to per- and polyfluoroalkyl substances (PFAS), particularly short-chain PFAS, on fetal reproductive hormones is limited and inconsistent. This study aimed to assess the relationship between maternal PFAS exposure and fetal reproductive hormones. A total of 752 mother-infant pairs who were recruited in the Shanghai Birth Cohort Study between 2013 and 2016 were selected. We quantified 10 PFAS, including two short-chain PFAS congeners (perfluorobutanesulfonate, PFBS and perfluoroheptanoic acid, PFHpA), in maternal blood plasma in early pregnancy. Dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (TT) were measured in the umbilical cord blood using chemiluminescence kits. Free androgen index (FM) was calculated by TT divided by SHBG. Multiple linear regression found that one In-unit increase in maternal PFBS was associated with decreases in FSH (-0.159; 95% CI: -0.290, -0.029), LH (-0.113; 95% CI: -0.221, -0.004), and FM (-0.009; 95% CI: -0.017, -0.001). In addition, PFHpA showed negative associations with LH (-0.154; 95% CI: -0.297, -0.011) and FM (-0.008; 95% CI: -0.014, -0.002). When PFAS were analyzed in quartiles, significant negative associations were observed between PFBS and FSH, and between PFHpA and FAL Overall, prenatal exposure to PFBS and PFHpA was associated with the disturbance of fetal gonadotropins as well as free androgen level in this prospective cohort, suggesting that the reproductive toxicity of short-chain PFAS may not be neglected.
引用
收藏
页码:8291 / 8299
页数:9
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