Systems immunology of human malaria

被引：26
作者：
Trani, Tuan M. [1 ]
Samai, Babru
Kirkness, Ewen [2 ]
Cromptoni, Peter D. [1 ]
机构：
[1] NIAID, Lab Immunogenet LIG, NIH, Rockville, MD 20852 USA
[2] J Craig Venter Inst, Genom Med Grp, Rockville, MD 20850 USA
来源：
TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 06期
关键词：
systems immunology; malaria; Plasmodium falciparum; HUMORAL IMMUNE-RESPONSE; PATTERN-RECOGNITION RECEPTORS; YELLOW-FEVER VACCINE; PLASMODIUM-FALCIPARUM; ACQUIRED-IMMUNITY; CEREBRAL MALARIA; RNA-SEQ; EXPRESSION; GENOME; PROTECTION;
D O I：
10.1016/j.pt.2012.03.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Plasmodium falciparum malaria remains a global public health threat. Optimism that a highly effective malaria vaccine can be developed stems in part from the observation that humans can acquire immunity to malaria through experimental and natural P. falciparum infection. Recent advances in systems immunology could accelerate efforts to unravel the mechanisms of acquired immunity to malaria. Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied.
引用
收藏
页码：248 / 257
页数：10
相关论文
共 105 条
  • [1] Deconvolution of Blood Microarray Data Identifies Cellular Activation Patterns in Systemic Lupus Erythematosus
    Abbas, Alexander R.
    Wolslegel, Kristen
    Seshasayee, Dhaya
    Modrusan, Zora
    Clark, Hilary F.
    [J]. PLOS ONE, 2009, 4 (07):
  • [2] A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
    Aderem, Alan
    Adkins, Joshua N.
    Ansong, Charles
    Galagan, James
    Kaiser, Shari
    Korth, Marcus J.
    Law, G. Lynn
    McDermott, Jason G.
    Proll, Sean C.
    Rosenberger, Carrie
    Schoolnik, Gary
    Katze, Michael G.
    [J]. MBIO, 2011, 2 (01):
  • [3] First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children
    Agnandji, Selidji Todagbe
    Lell, Bertrand
    Soulanoudjingar, Solange Solmeheim
    Fernandes, Jose Francisco
    Abossolo, Beatrice Peggy
    Conzelmann, Cornelia
    Methogo, Barbara Gaelle Nfono Ondo
    Doucka, Yannick
    Flamen, Arnaud
    Mordmueller, Benjamin
    Issifou, Saadou
    Kremsner, Peter Gottfried
    Sacarlal, Jahit
    Aide, Pedro
    Lanaspa, Miguel
    Aponte, John J.
    Nhamuave, Arlindo
    Quelhas, Diana
    Bassat, Quique
    Mandjate, Sofia
    Macete, Eusebio
    Alonso, Pedro
    Abdulla, Salim
    Salim, Nahya
    Juma, Omar
    Shomari, Mwanajaa
    Shubis, Kafuruki
    Machera, Francisca
    Hamad, Ali Said
    Minja, Rose
    Mpina, Maxmillian
    Mtoro, Ali
    Sykes, Alma
    Ahmed, Saumu
    Urassa, Alwisa Martin
    Ali, Ali Mohammed
    Mwangoka, Grace
    Tanner, Marcel
    Tinto, Halidou
    D'Alessandro, Umberto
    Sorgho, Hermann
    Valea, Innocent
    Tahita, Marc Christian
    Kabore, William
    Ouedraogo, Sayouba
    Sandrine, Yara
    Guiguemde, Robert Tinga
    Ouedraogo, Jean Bosco
    Hamel, Mary J.
    Kariuki, Simon
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (20) : 1863 - 1875
  • [4] Strategies to discover regulatory circuits of the mammalian immune system
    Amit, Ido
    Regev, Aviv
    Hacohen, Nir
    [J]. NATURE REVIEWS IMMUNOLOGY, 2011, 11 (12) : 873 - 880
  • [5] Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children
    Armah, Henry B.
    Wilson, Nana O.
    Sarfo, Bismark Y.
    Powell, Michael D.
    Bond, Vincent C.
    Anderson, Winston
    Adjei, Andrew A.
    Gyasi, Richard K.
    Tettey, Yao
    Wiredu, Edwin K.
    Tongren, Jon Eric
    Udhayakumar, Venkatachalam
    Stiles, Jonathan K.
    [J]. MALARIA JOURNAL, 2007, 6 (1)
  • [6] Cellular Decision Making and Biological Noise: From Microbes to Mammals
    Balazsi, Gabor
    van Oudenaarden, Alexander
    Collins, James J.
    [J]. CELL, 2011, 144 (06) : 910 - 925
  • [7] Metabonomic investigation of human Schistosoma mansoni infection
    Balog, Crina I. A.
    Meissner, Axel
    Goraler, Sibel
    Bladergroen, Marco R.
    Vennervald, Birgitte J.
    Mayboroda, Oleg A.
    Deelder, Andre M.
    [J]. MOLECULAR BIOSYSTEMS, 2011, 7 (05) : 1473 - 1480
  • [8] Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
    Bendall, Sean C.
    Simonds, Erin F.
    Qiu, Peng
    Amir, El-ad D.
    Krutzik, Peter O.
    Finck, Rachel
    Bruggner, Robert V.
    Melamed, Rachel
    Trejo, Angelica
    Ornatsky, Olga I.
    Balderas, Robert S.
    Plevritis, Sylvia K.
    Sachs, Karen
    Pe'er, Dana
    Tanner, Scott D.
    Nolan, Garry P.
    [J]. SCIENCE, 2011, 332 (6030) : 687 - 696
  • [9] A Plaidoyer for 'systems immunology'
    Benoist, C
    Germain, RN
    Mathis, D
    [J]. IMMUNOLOGICAL REVIEWS, 2006, 210 : 229 - 234
  • [10] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Berry, Matthew P. R.
    Graham, Christine M.
    McNab, Finlay W.
    Xu, Zhaohui
    Bloch, Susannah A. A.
    Oni, Tolu
    Wilkinson, Katalin A.
    Banchereau, Romain
    Skinner, Jason
    Wilkinson, Robert J.
    Quinn, Charles
    Blankenship, Derek
    Dhawan, Ranju
    Cush, John J.
    Mejias, Asuncion
    Ramilo, Octavio
    Kon, Onn M.
    Pascual, Virginia
    Banchereau, Jacques
    Chaussabel, Damien
    O'Garra, Anne
    [J]. NATURE, 2010, 466 (7309) : 973 - U98
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