Xylopidimers A-E, Five New Guaiane Dimers with Various Carbon Skeletons from the Roots of Xylopia vielana

被引:10
作者
Guo, Yi-Gong [1 ]
Xie, Yang-Guo [1 ]
Wu, Guo-Jing [1 ]
Cheng, Tao-Fang [1 ]
Zhu, Sheng-Lan [1 ]
Yan, Shi-Kai [1 ]
Jin, Hui-Zi [1 ,3 ]
Zhang, Wei-Dong [1 ,2 ,3 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
[2] Shanghai Univ Tradict Chinese Med, Inst Interdisciplinary Sci, Shanghai 201203, Peoples R China
[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
来源
ACS OMEGA | 2019年 / 4卷 / 01期
关键词
AETHIOPICA;
D O I
10.1021/acsomega.8b00828
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Five new guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 mu M in RAW264.7 cells stimulated by lipopolysaccharide.
引用
收藏
页码:2047 / 2052
页数:6
相关论文
共 15 条
  • [1] [Anonymous], 1580265 CCDC
  • [2] [Anonymous], 1580262 CCDC
  • [3] [Anonymous], 1580267 CCDC
  • [4] [Anonymous], 1580259 CCDC
  • [5] [Anonymous], 1580260 CCDC
  • [6] Phenylpropanoid glycosides from Scrophularia scorodonia:: In vitro anti-inflammatory activity
    Díaz, AM
    Abad, MJ
    Fernández, L
    Silván, AM
    De Santos, J
    Bermejo, P
    [J]. LIFE SCIENCES, 2004, 74 (20) : 2515 - 2526
  • [7] Editor Committee, 2011, FLORA CHINA, V19, P689
  • [8] Guaiane dimers from Xylopia vielana
    Kamperdick, C
    Phuong, NM
    Adam, G
    Van Sung, T
    [J]. PHYTOCHEMISTRY, 2003, 64 (04) : 811 - 816
  • [9] Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana
    Karioti, A
    Hadjipavlou-Litina, D
    Mensah, MLK
    Fleischer, TC
    Skaltsa, H
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (26) : 8094 - 8098
  • [10] A sesquiterpene dimer from Xylopia aromatica
    Martins, D
    Osshiro, E
    Roque, NF
    Marks, V
    Gottlieb, HE
    [J]. PHYTOCHEMISTRY, 1998, 48 (04) : 677 - 680