机构:
Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
Jin, Hui-Zi
[1
,3
]
Zhang, Wei-Dong
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
Shanghai Univ Tradict Chinese Med, Inst Interdisciplinary Sci, Shanghai 201203, Peoples R China
Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
Zhang, Wei-Dong
[1
,2
,3
]
机构:
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
[2] Shanghai Univ Tradict Chinese Med, Inst Interdisciplinary Sci, Shanghai 201203, Peoples R China
[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
来源:
ACS OMEGA
|
2019年
/
4卷
/
01期
关键词:
AETHIOPICA;
D O I:
10.1021/acsomega.8b00828
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Five new guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 mu M in RAW264.7 cells stimulated by lipopolysaccharide.